2016年3月16日 · General controlled non-repressed (GCN2) kinase is a key orchestrator of the ISR, and modulates protein synthesis in response to amino acid starvation. Here we demonstrate in mice that...

2016年5月10日 · Indeed, mice fed a 2% low-protein diet or a leucine-deficient diet were protected from clinical symptoms of colitis and gut inflammation in a GCN2-dependent manner. Overall, this work highlights mechanisms by which GCN2 can dampen intestinal inflammation through induction of autophagy and reduction of inflammasome activity during cellular ...

Tissue-specific knockdown of GCN2 in the gut and fat body, two energy-sensing organs in Drosophila which are counterparts of mammalian liver and adipose tissue, abolishes the beneficial effect of dietary amino acid restriction on lifespan (Kim et al., 2020).

2023年9月20日 · GCN2是在所有真核生物中发现的最进化保守的eIF2AK，其功能是通过调节细胞类型特异性功能来调节生理和病理进程，包括代谢、免疫、癌症等。 与此同时一些证据表明GCN2在调节巨噬细胞（Mφ）功能中起着关键作用，GCN2的缺失导致腹膜Mφ对dsDNA病毒感染的易感性增加。 Mφ在调节红细胞（RBCs）的产生和清除之间的平衡方面也发挥着核心作用，尤其对于在急性失血或溶血等应激条件下促进红细胞的生产。 红细胞在骨髓（BM）中的红细胞 …

2018年2月14日 · Following the activation of GCN2, a series of events occur that prevent gut inflammation 2. In addition to the phosphorylation of eIF2α by GCN2, other mechanisms contribute to gut...

2016年3月24日 · General controlled non-repressed (GCN2) kinase is a key orchestrator of the ISR, and modulates protein synthesis in response to amino acid starvation. Here we demonstrate in mice that GCN2 controls intestinal inflammation by suppressing inflammasome activation.

2016年5月10日 · In a recent paper, Ravindran et al. (2016) uncovered a novel mechanism by which an amino acid sensing pathway controls inflammation in the gut. Metabolic stressors are emerging as important controls over immune system function.

2016年3月3日 · General controlled nonrepressed (GCN2) kinase is a key orchestrator of the ISR, and modulates cellular metabolism in response to amino acid starvation. Here we demonstrate that GCN2 controls intestinal inflammation by suppressing inflammasome activation.

2016年3月1日 · CD11c+ APC 或肠上皮细胞中 Gcn2（也称为 Eif2ka4）的基因缺失导致炎症体激活和白细胞介素 (IL)-1β 产生增强，从而导致肠道炎症和辅助 T 17 细胞 (TH17) 反应增强。

General controlled non-repressed (GCN2) kinase is a key orchestrator of the ISR, and modulates protein synthesis in response to amino acid starvation. Here we demonstrate in mice that GCN2 controls intestinal inflammation by suppressing inflammasome activation.