GGCX promotes Eurasian avian-like H1N1 swine influenza virus
2025年1月15日 · Knocking out the enzyme gamma glutamyl carboxylase (GGCX) reduces virus replication in vitro and in vivo by inhibiting the carboxylation modification of viral …
Single-cell transcriptomic analysis reveals the commonality of …
2024年10月31日 · Intercellular cross-talk analysis highlighted enhanced interactions among bystander immune cells during H1N1 infection, with neutrophils in humans and macrophages …
Influenza A Virus (H1N1) Infection Induces Glycolysis to Facilitate ...
2021年9月14日 · In this study, we show that glycolysis is upregulated in H1N1-infected human lung epithelial (A549) cells and mouse lung tissues and that inhibiting this metabolic pathway …
HIF-1α promotes virus replication and cytokine storm in H1N1 …
2024年2月1日 · HIF-1α is one of the major host molecules that facilitates H1N1 replication and promotes cytokine storm. Mortality was decreased in HIF-1α knockdown mice infected with …
H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the ... - Cell …
Ruan et al. show that H1N1 influenza A virus cross-activates Gli1, a transcription factor in the sonic hedgehog pathway. Gli1 activation plays a role in downregulating the expression of …
Transcriptional repressor Capicua is a gatekeeper of cell-intrinsic ...
2 天之前 · Manivasagam et al. describe a novel mechanism by which the evolutionarily conserved CIC-ATXN1L transcriptional repressor complex regulates IFN and ISGs under both …
Systems immunology analysis of human immune organoids ... - Cell …
2025年2月21日 · Wagoner and Yates et al. leverage tonsil organoids to explain heterogeneity in human immune responses to influenza vaccination. They identify novel predictors (Th1 …
Pandemic H1N1 influenza virus triggers a strong T helper cell …
2024年3月1日 · In the current study, human memory (M) and naïve (N) T cells responses in mononuclear cells of tonsil (TMCs) and peripheral blood (PBMCs) were stimulated by …
Unique Immune and Other Responses of Human Nasal Epithelial Cells …
2 天之前 · We infected human nasal epithelial cells (hNECs) cultured at the air-liquid interface from multiple healthy donors with clinical isolates of major human seasonal influenza viruses …
An Effective Neutralizing Antibody Against Influenza Virus H1N1 …
2019年3月14日 · In this study, we identified a fully human H1N1 neutralizing antibody (32D6) via an Epstein-Barr virus-immortalized B cell-based technology. 32D6 specifically neutralizes the …