2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial...

2024年10月9日 · Interferon regulatory factors (IRFs) constitute a comprehensive category of transcription factors initially identified as regulators of type I interferon (IFN-I) and IFN-responsive genes, and their...

2024年12月25日 · IRF7 (Interferon Regulatory Factor 7) is a Protein Coding gene. Diseases associated with IRF7 include Immunodeficiency 39 and Primary Immunodeficiency With Predisposition To Severe Viral Infection. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and SARS-CoV-2 Infection.

（1）Bax/Bcl-2：Bax是促凋亡基因，其可被p53诱导表达，对肿瘤有抑制作用。 在细胞凋亡时表达增加。 Bcl-2是凋亡抑制基因，其编码的蛋白具有抑制细胞凋亡的作用，且不影响细胞增殖。 Bcl-2与Bax是同源基因，两者共同构成了细胞凋亡的微调变阻器。 因此以两者的比值作为凋亡的指示是有一定意义的。 （2）Caspase-3/8：Caspase系统的激活对于细胞凋亡的发生至关重要，因此Caspase家族蛋白在细胞凋亡时表达均增加。

2023年8月28日 · IRF7 interacted with the pro-inflammatory transcription factor NF-κB-p65 and inhibited the induction of inflammatory target genes. Using knockdown, knockout, and overexpression strategies, we demonstrated that IRF7 inhibited NF-κB–dependent inflammatory target genes, induced by virus infection or toll-like receptor stimulation.

2024年2月14日 · Changes in the expression of IRF3, IRF7, IFN-β, BAK, BAX, and BCL-2 genes were evaluated. The levels of proinflammatory cytokines of IL-6, IL-12, IL-1β, and TNF-α were also determined. The N...

2019年6月1日 · The pro-apoptotic gene Bax increased in both IRF7-Δ7 and IRF7-Δ11 cells, while the anti-apoptotic gene, Bcl-2, showed a significant increase only in IRF7-Δ11 cells (Fig. 3d). We believe that these differential changes in the two IRF7 -mutant cell lines reflect mechanisms underlying the significant attenuation in the growth of these cell ...

The LUBAC-mediated linear ubiquitination of IRF3 leads to its translocation to the mitochondria and interaction with BAX. Mitochondrial translocation of IRF3/BAX complex leads to cytochrome C release that activates the apoptotic caspases, leading to apoptotic cell death.

2021年1月1日 · AAV-IRF7 pretreatment decreases the ATF3, PCNA, and cyclinD1 levels, coupled with increases in the levels of the Bax/Bcl2 ratio and cleaved caspase-3 in pulmonary artery smooth muscle cells (PASMCs) of MCT-induced PH rats, and these effects can be reversed by AAV-ATF3.

Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs) family, is located downstream of the pattern recognition receptors (PRRs)-mediated signaling pathway and is essential for the production of type I interferon ...