What Is the Role of 2-Pore Domain Potassium Channels (K2P) in Pain?
2022年9月19日 · Ambrosino P, Soldovieri MV, Di Zazzo E, et al. Activation of Kv7 potassium channels inhibits intracellular Ca (2+) increases triggered by TRPV1-mediated pain-inducing …
Two‐pore domain potassium channels: emerging targets for novel ...
Among these, a growing body of evidence supports a role for the two‐pore domain potassium (K2P) family of K + channels. Here, we provide a concise review of the K2P channels, their …
Two-pore domain potassium channels: emerging targets for …
2018年10月16日 · Among these, a growing body of evidence supports a role for the two-pore domain potassium (K2P) family of K + channels. Here, we provide a concise review of the K2P …
2 孔域钾通道 (K2P) 在疼痛中的作用是什么？,Neurology - X-MOL
Given their importance in pain modulation, voltage-gated K channels (K) and 2-pore domain K channels (K2P) are potential targets for designing novel analgesic compounds. This review will …
Two-pore domain potassium channels: potential therapeutic ... - PubMed
Recent evidence points to a pivotal contribution of a variety of different potassium channels, including two-pore domain potassium (K2P) channels, in chronic pain processing. Expression …
神经性疼痛中的钾通道：进展，挑战和新出现的想法。,Pain - X-MOL
2016年1月20日 · 在整个审查过程中，钾离子通道在疼痛中的作用是显而易见的，这使它们成为创新镇痛药的潜在目标，根据通道的不同，其具有周围和/或中央作用。 显然，用已知或新颖的 …
Regulation of two-pore-domain potassium TREK channels and …
2022年3月16日 · The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that transduce noxious stimuli into pain. Among …
Emerging potassium channel targets for the treatment of pain
Recent findings: We now recognize that certain K+ channel subunits are directly gated to pain-relevant stimuli (Kv1.1, K2P) whereas others are specifically modulated by inflammatory …
A Role for K2P Channels in the Operation of Somatosensory …
2012年3月5日 · The ability to sense mechanical, thermal, and chemical stimuli is critical to normal physiology and the perception of pain. Contact with noxious stimuli triggers a complex series …
Two-pore domain potassium channels: potential therapeutic
2014年11月26日 · Recent evidence points to a pivotal contribution of a variety of different potassium channels, including two-pore domain potassium (K2P) channels, in chronic pain …