近日， 美国国立儿童健康和人类发育研究所 的研究人员在 Nature 子刊 Nature Communications 杂志上发表题为：Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility 的研究论文。 此项研究描述了一种Pin1 依赖机制，它可以调节A型钾离子通道亚型——Kv4.2与其附主亚基DDPP6的关联，从而改变神经元的兴奋性和认知灵活性。 这项研究可能最终增强人们对人的认知灵活性的认识。 还可能有助于增进对 癫痫 、 精神分裂症 、 脆性X综合征 和 自闭症 的 …

2022年1月8日 · 在 Kv 通道的 12 个亚家族中，Kv4 (Kv4.1–Kv4.3) 通道介导瞬时外向 A 型电流，其特点是在亚阈值膜电位下快速激活、快速失活和从失活状态快速恢复 。 在神经元中，Kv4 位于胞体和树突，在那里它控制缓慢重复性尖峰放电的频率并减弱动作电位的反向传播。

2020年12月1日 · The voltage-gated potassium channel Kv4.2 is a critical regulator of dendritic excitability in the hippocampus and is crucial for dendritic signal integration. Kv4.2 mRNA and protein expression as well as function are reduced in several genetic and pharmacologically induced rodent models of epilepsy and autism.

2020年3月26日 · We show that activity-induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerization of, Kv4.2 at the pThr 607 -Pro motif, leading to the dissociation of the Kv4.2-DPP6 complex. We...

2021年8月20日 · Here, we show that Kv4.2 channels selectively modulate the excitability of medial dendrites of dentate GCs. These dendrites are targeted by the medial entorhinal cortex, the main source of spatial inputs to the DG. Accordingly, we found that the spatial pattern separation capability of animals lacking the Kv4.2 channel is significantly impaired.

2009年5月14日 · Kv4.2 is the major voltage-gated K + (Kv) channel α subunit responsible for the somatodendritic transient or A-type current I SA that activates at subthreshold membrane potentials. Stable association of Kv4.2 with diverse auxiliary subunits and reversible Kv4.2 phosphorylation regulate I SA function.

5 天之前 · Kv4.2 subunits, which mediate transient A-type K+ current, are crucial in regulating neuronal excitability and synaptic responses within the hippocampus. While their contribution to activity-dependent regulation of synaptic response is well-established, the impact of Kv4.2 on basal synaptic strength remains elusive. To address this gap, we introduced a Kv4.2-specific antibody (anti-Kv4.2) into ...

Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus. The sequence of Kv4.2 contains several consensus sites for ERK phosphorylation. In the present studies, we tested the hypothesis that Kv4.2 is …

Shal型钾离子通道 也称为KV4.1、KV4.2和KV4.3（哺乳动物），在大脑和心脏中高度表达，分别调节神经元兴奋性和心脏起搏等多种生理功能。在衰老及其相关疾病的背景下，本文将主要关注这些类型的钾离子通道。

Rapidly activating and rapidly inactivating voltage-gated A-type K+ currents, IA, are key determinants of neuronal excitability and several studies suggest a critical role for the Kv4.2 pore-forming α subunit in the generation of IA channels in ...