Amino acid transporter LAT1 (SLC7A5) as a molecular target for …
2022年2月1日 · The inhibition of LAT1 suppresses protein synthesis by downregulating the mTORC1 signaling pathway and mobilizing the general amino acid control (GAAC) pathway in …
氨基酸转运蛋白 LAT1 (SLC7A5) 作为癌症诊断和治疗 ... - X-MOL
LAT1 对癌细胞生长至关重要，因为 LAT1 的药理学抑制和敲低/敲除可抑制癌细胞的增殖和异种移植肿瘤的生长。 LAT1 的抑制通过下调 mTORC1 信号通路和调动癌细胞中的一般氨基酸控制 …
Targeting Amino Acid Metabolic Vulnerabilities in Myeloid …
2021年5月20日 · Glutamine and or glutamate is imported into cells via several transporters including system L and y + transporters (LAT1, y + LAT1, and y + LAT2), the …
The Regulation and Function of the L-Type Amino Acid …
Increasing the uptake of leucine into cells is the most effective way that LAT1 promotes the activity of Mechanistic Target of Rapamycin Kinase Complex 1 (mTORC1). LAT1 not only …
“脑癌”潜力靶点LAT1，药物设计思路清晰 - 网易
2021年9月30日 · LAT（L-type amino transporters），即L型氨基酸转运体，主要功能为中性氨基酸包括必须氨基酸的转运，亚型按照时间发现顺序依次为LAT1、LAT2、LAT3、LAT4，其 …
L-Type amino acid transporter 1 as a target for drug delivery
Due to the significant up-regulation of LAT1 expression in several human tumors, LAT1 has been an attractive transporter for targeted delivery of amino acid-derived anticancer drugs and …
Nature Reviews | 靶向肿瘤代谢的精准治疗 - 知乎 - 知乎专栏
与v-9302的抗肿瘤活性及其对l型氨基酸转运体1（lat1）依赖的中性氨基酸转运的抑制一致，lat1在kras突变的结直肠癌(crc)模型中被发现对肿瘤的发生至关重要。
LAT1, a novel pharmacological target for the treatment of
The L-Type Amino Acid transporter, LAT1 (SLC7A5), has a crucial role in mediating amino acid uptake into the cells, thus modulating cell growth and proliferation as well as other intracellular …
The Role of Large Neutral Amino Acid Transporter (LAT1) in Cancer
LAT1 (also known as SLC7A5), is defined as a heteromeric amino acid transporter (HAT) interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide to uptake not …
Association of L-type amino acid transporter 1 (LAT1) with the
2022年2月17日 · Our findings suggest that LAT1 might be a candidate therapeutic target for breast cancer patients, particularly those with luminal B-like type breast cancer. The survival of …
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