2021年8月2日 · Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases. In this review, we describe our current understanding of LLPS and summarize its...

2024年12月1日 · In this review, we introduce the insights and findings on the formation, regulation and function of LLPS. The role of LLPS in human diseases, including cancer, neurodegenerative diseases, and viral infections, is described, and latest progress in the pathological mechanisms of related diseases and their therapeutic options are summarized.

Liquid-liquid phase separation (LLPS) is a process in which certain proteins or protein-RNA complexes form phase-separated droplets with different components and properties through multivalent interactions within a cell. In recent years, the role of LLPS in immunomodulation has received extensive attention.

This review will summarize the principle and components of LLPS, and describe how LLPS regulate these numerous biological processes and disruption of LLPS would cause disease formation. The role of LLPS in regulating normal cellular physiology and contributing to tumorigenesis will be discussed.

2023年12月1日 · This review offers a concise overview of LLPS in soft matter, emphasizing its relevance in soft material engineering. We delve into fundamental mechanisms, focusing on biological systems, and explore the implications of LLPS, spanning organelles, substance exchange, molecular diffusion, and disease associations.

2024年11月1日 · LLPS describes a phenomenon that different components in cells collide and fuse with each other to form droplets, so that some components are wrapped in droplets and some components are blocked outside droplets. Physical forces between proteins or RNA molecules can cause them to separate or aggregate.

2024年1月20日 · Liquid–liquid phase separation (LLPS) in biology describes a process by which proteins form membraneless condensates within a cellular compartment when conditions are met, including the concentration and posttranslational modifications of the protein components, the condition of the aqueous solution (pH, ionic strength, pressure, and ...

2021年8月15日 · Liquid-liquid phase separation (LLPS) has emerged as a mechanism that has been used to explain the formation of known organelles (e.g. nucleoli, promyelocytic leukemia nuclear bodies (PML NBs), etc) as well as other membraneless condensates (e.g. nucleosome arrays, DNA damage foci, X-chromosome inac …

2021年8月2日 · Emerging evidence suggests that liquid-liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets). Recent studies have revealed evidences that indicate that L …

2024年9月17日 · Here, we comprehensively summarize the multifaceted roles of LLPS in tumor biology from the perspective of cancer hallmarks, including genomic stability, metabolic reprogramming progression, ferroptosis, and metastasis, to unveil the intricate mechanisms by which LLPS occurs in tumorigenesis.