周强组解析首个人源氨基酸转运体LAT1–4F2hc复合体结构_光谱网
3 天之前 · 2019年3月14日，西湖大学生物学研究所周强研究员团队在Nature发表了题为Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex的论文（第一单位为清 …
The Role of Large Neutral Amino Acid Transporter (LAT1) in Cancer
LAT1 (also known as SLC7A5), is defined as a heteromeric amino acid transporter (HAT) interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide to uptake not …
Structure of the human LAT1–4F2hc heteromeric amino acid …
2019年3月13日 · Here we report the cryo-electron microscopy structures of human LAT1–4F2hc alone and in complex with the inhibitor 2-amino-2-norbornanecarboxylic acid at resolutions of …
The complete assembly of human LAT1-4F2hc complex provides …
2024年5月2日 · The L-type amino acid transporter 1 (LAT1, SLC7A5) is one of the most important HATs since it plays a pivotal role in facilitating uptake of large neutral...
Mechanism of substrate transport and inhibition of the human LAT1 …
2021年3月23日 · LAT1 (SLC7A5) is one of the representative light chain proteins of heteromeric amino acid transporters, forming a heterodimer with its heavy chain partner 4F2hc (SLC3A2). …
The Role of Large Neutral Amino Acid Transporter (LAT1) in Cancer
LAT1 (also known as SLC7A5), is defined as a heteromeric amino acid transporter (HAT) interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide to uptake not …
Structural basis for the substrate recognition and transport ... - AAAS
6 天之前 · Heteromeric amino acid transporters (HATs), including y + LAT1-4F2hc complex, are responsible for transporting amino acids across membranes, and mutations in y + LAT1 cause …
LAT1 - Transporters - Solvo Biotechnology
Like all members of the heteromeric amino acid transporter (HAT, SLC7) family, LAT1 resides in the plasma membrane in a heterodimeric form. The LAT1 holotransporter consists of a 55-kDa …
The human LAT1–4F2hc (SLC7A5–SLC3A2) transporter complex: …
One of the best characterized HATs is the system L transporter LAT1–4F2hc. 2, 4, 5 LAT1–4F2hc mediates the cellular uptake of large neutral amino acids such as leucine, isoleucine, valine, …
周强课题组报道人源氨基酸转运蛋白LAT1-4F2hc ... - Westlake
lat1-4f2hc是人体内的一种氨基酸转运蛋白复合物，属于异源多聚体氨基酸转运蛋白（hat）家族。该家族成员由轻链蛋白和重链蛋白构成。lat1是其中的轻链蛋白，负责转运大的不带电的氨基 …
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