2006年1月17日 · MBP consists of a number of posttranslationally modified isomers of varying charge, some resulting from phosphorylation at several sites by different kinases, including mitogen-activated protein kinase (MAPK). Phosphorylation of MBP in oligodendrocytes occurs in response to various extracellular stimuli.

2022年3月9日 · Here, we report that mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP1) and its target kinases MPK3 and MPK6 form a signaling cascade that promotes vascular defense in both Arabidopsis and rice. We found that nonhost resistance (NHR) to Xoo is lost in Arabidopsis mkp1 mutant, leading to Xoo growth in the leaf veins.

2005年12月15日 · MBP consists of a number of posttranslationally modified isomers of varying charge, some resulting from phosphorylation at several sites by different kinases, including mitogen-activated protein kinase (MAPK). Phosphorylation of MBP in oligodendrocytes occurs in response to various extracellular stimuli.

p38激酶参与控制细胞对细胞因子和应激反应的信号级联， 哺乳动物中有四种p38激酶:p38α (MAPK14)、β (MAPK11)、γ (MAPK12)和δ (MAPK13 )。 与JNK途径相似，p38激酶被多种细胞应激激活，包括渗透休克、炎性细胞因子、脂多糖 (lps)、紫外线和生长因子。 此外，氧化应激和G蛋白偶联受体刺激间接激活p38。 p38通路在转录和翻译水平上是促炎细胞因子生物合成的关键调节因子，这使得该通路的不同组分成为治疗自身免疫和炎性疾病的潜在靶点。

2015年1月1日 · Mitogen-activated protein kinase (MAPK) cascades are universal, evolutionary conserved signalling modules, which translate environmental information into appropriate responses via phosphorylation of their substrate proteins. In Arabidopsis, the MAPK MPK3 regulates numerous cellular processes, including the adaptation to abiotic and biotic stresses.

2023年11月1日 · The in-silico design of a multiepitope-based-peptide (MBP) vaccine involves the computational identification of potential epitopes within a specific MAPK protein associated with Alzheimer's disease, followed by the selection of immunogenic epitopes, and the incorporation of these epitopes into a single peptide sequence.

Myelin basic protein (MBP) phosphorylation is a complex regulatory process that modulates the contribution of MBP to the stability of the myelin sheath. Recent research has demonstrated the modulation of MBP phosphorylation by mitogen-activated protein kinase (MAPK) during myelinogenesis and in the …

2001年12月25日 · Recent research has demonstrated the modulation of MBP phosphorylation by mitogen‐activated protein kinase (MAPK) during myelinogenesis and in the demyelinating disease multiple sclerosis.

2002年2月28日 · Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a...

2021年12月24日 · 丝裂原活化蛋白激酶（mitogen-activated protein kinase，MAPK）是一组能被不同的细胞外刺激，如细胞因子、神经递质、激素、细胞应激及细胞黏附等激活的丝氨酸-苏氨酸蛋白激酶。 由于MAPK是培养的细胞在受到生长因子等丝裂原刺激时被激活而被鉴定的，因而得名。 （备注: 所谓丝裂原即有丝分裂原，因可非特异性激活多克隆T、B细胞发生有丝分裂而得名）。 这个通路虽然是在动物细胞中发现的，但所有的真核细胞都能表达MAPK。 MAPK通路的基本组 …