Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in
2024年7月3日 · A labeled LDL complex (LDL-BODIPY) was used to assess the inhibitory effects of the Abs on PCSK9, and the mean fluorescence intensity (MFI) was measured as an …
RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol …
2023年3月6日 · Removal of circulating plasma low-density lipoprotein cholesterol (LDL-C) by the liver relies on efficient endocytosis and intracellular vesicle trafficking. Increasing the …
流式数据分析 | 平均荧光强度Mean Fluorescence Intensity (MFI)
平均荧光强度(Mean Fluorescence Intensity, MFI)是描述偶联抗体的信号强弱的一种方法。 我们在阅读文献时，一般看到的MFI有两种：Mean Fluorescence Intensity或Median Fluorescence …
Apolipoprotein B Binding Domains: Evidence That They Are Cell ...
2011年4月15日 · Apolipoprotein B-100 (ApoB-100), the sole protein component of LDL, is known to bind to cell surface LDL receptor (LDLR) or cell surface-bound proteoglycans and to be …
Mechanistic studies reveal that EHBP1 promotes sortilin-mediated PCSK9 secretion, leading to LDL receptor (LDLR) degradation, decreased LDL uptake, and reduced TAZ, a fibrogenic …
MG132, a proteasome inhibitor, enhances LDL uptake in …
2014年7月21日 · In the current study, we employed MG132 to evaluate the potential effects of proteasome inhibition on LDL-c clearance via detection of the LDLR expression and function in …
Development of a PCSK9-targeted nanoparticle vaccine to …
2024年6月18日 · Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low-density lipoprotein receptor (LDLR) and mediates its internalization and degradation, resulting in an …
MEF2C regulates NK cell effector functions through control of lipid ...
2024年4月8日 · Loss of MEF2C lowered intracellular lipid content and uptake through decreased low-density lipoprotein receptor (LDLR) levels, and supplementation with oleic acid restored …
PCSK9及IDOL在姜黄素促进HepG2细胞摄取LDL-C中的作用
研究表明姜黄素可明显升高hepg2细胞ldlr的mrna及蛋白水平，通过激活srebp2并使得其靶基因ldlr表达水平增高 ，起到降脂的作用。
LDLR的调控机制及其相关疾病与药物研究进展 - Magtech
2025年3月2日 · 低密度脂蛋白受体（low density lipoprotein receptor, LDLR）参与胆固醇的代谢过程，在维持机体细胞胆固醇稳态中发挥着重要作用。 LDLR的表达受到转录、转录后及翻译后 …