Myeloperoxidate (MPO) is a hemoprotein present in leukocytes and catalyzes the hydrogen peroxide mediated peroxidation of halide ions to produce strong reactive oxidant species such as hypochlorous acid that are of potent antimicrobial activities against a broad range of invading parasites and pathogens.

MPO is a white blood cell-derived inflammatory enzyme that measures disease activity from the luminal aspect of the arterial wall. Briefly, when the artery wall is damaged, or inflamed, MPO is released by invading macrophages where it accumulates1.

Myeloperoxidase, or MPO, is an enzyme that is released by white blood cells called macrophages that measures your body’s response to damaged artery walls that have become thin, cracked, and ultimately unstable due to cholesterol accumulation and …

MPO is a white blood cell-derived inflammatory enzyme that measures disease activity from the luminal aspect of the arterial wall. Briefly, when the artery wall is damaged, or inflamed, MPO is released by invading macrophages where it accumulates.

Positive results for myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCA) by antigen-specific immunoassay and perinuclear ANCA by indirect immunofluorescence are consistent with the diagnosis of microscopic polyangiitis (MPA) or eosinophilic granulomatosis with polyangiitis, in patients with the appropriate clinical presentation.

Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. [5] MPO is most abundantly expressed in neutrophils (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach.

Myeloperoxidase Antibody (MPO) - Autoimmune vasculitis diseases are characterized by abnormal immune responses that result in inflammation and necrosis of blood vessels. The immune dysfunction may be triggered by infection, autoimmune disease, or exposure to a drug; often the cause is unknown.

Evaluating patients with clinical features anti-neutrophil cytoplasmic antibody associated vasculitis, specifically granulomatosis with polyangiitis, microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis.

What is the Myeloperoxidase (MPO) Test? The Myeloperoxidase (MPO) Test is a medical examination that evaluates the levels of myeloperoxidase, an enzyme primarily present in neutrophils and other white blood cells. It plays a key role in the immune system by aiding in the destruction of pathogens, such as bacteria and viruses.

MPO catalyzes the conversion of hydrogen peroxide to hypochlorite and hypochlorous acid. MPO is encoded by a single gene that undergoes posttranslational modification to produce the active enzyme found in leukocytes.