2019年5月7日 · We show that OTX2 activity modifies extracellular matrix components and signaling molecules produced by supporting astrocytes. Thus, we reveal a multilevel and non-cell-autonomous role of a homeoprotein and reinforce the choroid plexus and astrocytes as key niche compartments affecting adult neurogenesis.

2013年6月1日 · The Otx2 homeobox gene is one of the most important genes for forebrain induction and head formation in vertebrates. In mouse embryo, Otx2 is already transcribed from the embryonic morula stage, and in the murine blastula, …

2023年2月27日 · Here, we discover an unconventional nuclear export of the TF, orthodenticle homeobox 2 (OTX2), in nuclear budding vesicles, which transport OTX2 to the lysosome. We further find that torsin1a...

2024年12月25日 · OTX2 (Orthodenticle Homeobox 2) is a Protein Coding gene. Diseases associated with OTX2 include Microphthalmia, Syndromic 5 and Pituitary Hormone Deficiency, Combined, 6. Among its related pathways are Gastrulation and Nervous system development.

2021年5月7日 · Here, we investigated the consequences of reduced OTX2 levels in Otx2 heterozygote mice, as well as in Otx2 +/AA and scFvOtx2 tg/0 mouse models for decreasing OTX2 transfer from choroid...

2020年7月20日 · OTX2 is a potent oncogene that promotes tumor growth in Group 3 medulloblastoma. However, the mechanisms by which OTX2 represses neural differentiation are not well characterized. Here, we...

Transcription Factor Otx2 is a key regulatory protein involved in the development of the pituitary gland, playing a role in cell type determination and differentiation. You might find these chapters and articles relevant to this topic. Dorota Skowronska-Krawczyk, ... Michael G. Rosenfeld.

通过对组成型和条件敲低成年小鼠模型的 RNA 测序分析，我们揭示了 OTX2 在成年脉络丛功能中的假定功能作用，包括细胞信号传导和粘附，并表明 OTX2 调节分泌到脑脊液中的因子的表达，特别是甲状腺素运载蛋白。 我们还表明， Otx2表达会影响脉络丛免疫和应激反应，并影响剪接，导致参与氧化应激反应和 DNA 修复的蛋白质 mRNA 亚型发生变化。 通过对脉络丛中以及已知的非细胞自主目标区域（例如视觉皮层和室下区）中的 OTX2 蛋白伴侣进行质谱分析，我们确定了参 …

2010年11月18日 · Otx2 表达仅限于 VTA 神经元的相关部分，在 SNpc 中不存在。 特别是，Otx2 普遍被排除在背外侧 VTA 的神经元之外，后者表达 Girk2 和高水平的多巴胺转运蛋白 (Dat)。

2014年6月26日 · The transcription factor Otx2 plays an important role in neural development and in the exit of embryonic stem cells from the pluripotent ground state. In this study, Yang et al. demonstrate that Otx2 drives enhancer activation and maintenance during the early cell-fate transition away from ground state pluripotency.