p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene.

【摘要】 抑癌基因 p16ink4a在特异地抑制 CDK4及CDK6在控制细胞生长、 抑制肿瘤发生、 促进细胞衰老等方面发挥关键生物学作用, 该基因失活后造成了细胞周期调控失常,使得细胞异常增殖,造成了肿瘤发生、 发展, 本文就近几年来相关它在染色体上定位、 结构以及在细胞增殖、 癌变过程中研究进展作一综述。 p16ink4a基因最早作为肿瘤抑制基因由美国冷泉试验室在1994年发觉, 属于细胞周期依靠性激酶抑制基因 INK4家族 一员 [1], 在正常细胞中含有调控细胞周期作用, 负调整 …

Here, we report the presence of an instability determinant within the 3′-untranslated region (UTR) of the p16 messenger RNA in WI-38 human diploid fibroblasts. The p16 3′UTR was found to be a specific target of AUF1, an RNA-binding protein implicated in promoting mRNA decay.

This review focuses on p16, a crucial biomarker of cell senescence and molecular aging, the methodology of p16 measurement in humans, and the utility of p16 expression in guiding cancer treatments.

2023年8月31日 · Our results show that the presence of p16 High senescent cells limits cell plasticity, whereas their depletion can promote a totipotent-like state and histopathological tissue rejuvenation during...

2020年7月7日 · We found a significant increase in expression of p16 mRNA in Cd31-positive cells in 2-year-old mice (Figure 3 A). While most of the p16 mRNA expressions were detected in the Cd31-positive fraction in 2-month-old mice, a noticeable increase was also observed in the Cd31-negative fraction in 2-year-old mice.

2025年1月6日 · P16 全称为p16INK4a，是一种细胞周期调控蛋白。 它在细胞生长和分裂过程中的调控作用使它成为癌症研究中的关键。 P16的独特之处在于，它不仅是一个抑癌基因，还是一个能够通过多种机制抑制肿瘤生长的分子开关。 正是这种特性，使得P16被称为“抑癌基因”。

4 天之前 · UC-MSCs mitigate the aging of the thymus and spleen by regulating aging-related genes. (a - d) p16, p53, p21, and RB mRNA levels in the thymus. (e – h) p16, p53, p21, and RB mRNA levels in the ...

2025年3月11日 · The results regarding the relationship between P16 expression and HPV-16 integration status showed that the majority of samples with an episomal HPV-16 status exhibited low to no P16 expression ...

细胞衰老是诸多与之相关的基因或信号分子在环境因素作用下表达或修饰改变引起功能改变的“加合”结果.已发现至少上百个基因与衰老相关,但关键衰老相关基因的作用不可或缺.关键衰老相关基因p16INK4对衰老的发生与维持极其重要,探讨其调控机制一直是衰老 ...