Compared to WT and PDE3B KO mice, cyclic AMP-PDE activity in membrane fractions prepared from the hearts of PDE3A KO mice was lower and not inhibited by cilostamide. The data suggest that PDE3A is the main subtype of PDE3 expressed in platelets and cardiac ventricular myocytes, and is responsible for the functional changes caused by PDE3 ...

2011年12月1日 · PDE3B, one of several enzymes which hydrolyze cAMP and cGMP, is expressed in cells of importance for the regulation of energy homeostasis, including adipocytes, hepatocytes, hypothalamic cells and β cells.

2024年12月25日 · Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of lipid catabolic process; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction.

PDE3有两种基因亚型：PDE3A与PDE3B,分别位于染色体11与12上，由于起始密码子的不同，PDE3A又可分为PDE3A1、PDE3A2和 PDE3A3三种亚型,主要分布于心脏、血小板、血管平滑肌及卵母细胞中,具有调节心肌收缩力、血小板聚集、血管平滑肌收缩、卵母细胞成熟及肾素释放等作用。 PDE3B只有一种亚型PDE3B1，主要分布于脂肪细胞、肝细胞、精母细胞以及胰腺中，主要参与调节胰岛素，胰岛素样生长因子以及瘦素的信号传导，在肥胖和糖尿病等代谢性疾病中发挥 …

2002年7月8日 · These results indicate that a PI3K–PDE3B–cAMP pathway interacting with the Janus kinase 2 (Jak2)–Stat3 pathway constitutes a critical component of leptin signaling in the hypothalamus.

Results explain the dual cyclic AMP/cyclic GMP binding capabilities of phosphodiesterase 3B and provide the molecular basis for inhibitor specificity. Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia

Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of angiogenesis; negative regulation of cell adhesion; and negative regulation of lipid catabolic process. Located in membrane. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]

The main target of the antilipolytic action of insulin is believed to be phosphodiesterase 3B (PDE3B), whose phosphorylation by Akt leads to accelerated degradation of the prolipolytic second messenger cyclic AMP (cAMP). To test this hypothesis genetically, brown adipocytes lacking PDE3B were examined for their regulation of lipolysis.

为了研究环核苷酸对能量稳态机制的影响，通过环核苷酸磷酸二酯酶3b（Pde3b）基因的靶向失活产生了小鼠，该基因编码PDE3B，该酶催化cAMP和cGMP的水解并在调节能量稳态的组织中高度表达。

PDE3B 是水解 cAMP 和 cGMP 的几种酶之一，在对调节能量稳态具有重要意义的细胞中表达，包括脂肪细胞、肝细胞、下丘脑细胞和 β 细胞。 已经表明，在细胞和动物中使用 PDE3 抑制剂和基因靶向方法，PDE3B 水平的改变导致葡萄糖和脂质代谢的调节以及整体能量稳态的许多变化。 本文重点介绍了激素对 PDE3B 的调节以及 PDE3B 在几个相互作用组织中对下游代谢作用的调节所涉及的复杂性。 From PDE3B to the regulation of energy homeostasis. The incidence of …