RIP1 inhibition reduces RGC death and axonal degeneration following IRI in mice expressing OPTN-WT and OPTN-E50K variant mice. We demonstrate that RIP1 inactivation suppressed …

2024年10月24日 · RIP1 inhibition reduces RGC death and axonal degeneration following IRI in mice expressing OPTN-WT and OPTN-E50K variant mice. We demonstrate that RIP1 …

给予 RIP3 抑制剂 GSK872 和 RIP1 抑制剂 necrostatin-1 (Nec-1) 可防止谷氨酸诱导的 RGC 损失、视网膜损伤、神经炎症、ROS 的过度产生和 GSH 的减少。 此外，在 GSK872 和 Nec-1 抑 …

2007年2月15日 · In this review, we describe how RIP1 acts as a key integrator of signalling pathways initiated by stimulation of death receptors, bacterial or viral infection, genotoxic …

2024年2月15日 · Ripa-56, a new kind of receptor-interacting protein kinase (RIPK) 1 inhibitor that has been found to be more potent and devoid of off-target effects compared to Necrostatin-1...

Here, we show that RIP1 is abundantly expressed in infiltrating macrophages during angiogenesis, and genetic or pharmacological inhibition of RIP1 kinase activity using kinase …

We found that glutamate excitotoxicity induced necroptosis in RGCs through activation of the RIP1/RIP3/MLKL pathway in vivo and in vitro. Administration of the RIP3 inhibitor GSK872 and …

2022年11月24日 · In this Perspective, considering the structure, biological functions, and disease relevance of RIP1, we summarize the recent research progress in RIP1 small-molecule …

我们针对TNF-α诱导小鼠L929细胞的细胞坏死信号通路，利用免疫沉淀的方法纯化相关的蛋白复合物，结合Group-DIA质谱技术对相应的复合物蛋白进行鉴定及定量分析；基于得到的质谱数 …

RIP1 inhibition reduces RGC death and axonal degeneration following IRI in mice expressing OPTN-WT and OPTN-E50K variant mice. We demonstrate that RIP1 inactivation suppressed …