2006年8月23日 · Phosphorylation of substrates by Mst results in their activation or inactivation and subsequent downstream effects. Stabilization of Sav by Mst would enhance this process …

2017年10月24日 · The Hippo pathway controls tissue growth and homeostasis through a central MST-LATS kinase cascade. The scaffold protein SAV1 promotes the activation of this kinase …

2014年11月4日 · MST1/2-SAV1 regulates ciliogenesis through two independent mechanisms: MST1/2 binds and phosphorylates Aurora kinase A (AURKA), leading to dissociation of the …

In this study, we show that upstream regulators of the Hippo pathway form functionally antagonizing biomolecular condensates to regulate pathway activity. We further identify the …

蛋白激酶 Hippo信号通路 由保守的激酶构成，其核心成员是上游的激酶复合物有 MST /SAV/ LATS / MOB 和下游的转录复合物YAP/TAZ- TEADs 组成，YAP/TAZ-TEADs通过控制时间和空间特 …

有趣的是, MST1和MST2激酶可促进SAV1与PPARγ结合, 这种结合是由SAV1的WW结构域与PPARγ的PPXY模体介导。 在3T3-L1细胞中, SAV1表达会稳定PPARγ蛋白水平, 而SAV1敲低 …

pression of Mst and hSav led to phosphorylation of hSav and also increased its abundance. In vitro phosphorylation experiments indicate that the phos-phorylation of Sav by Mst is direct. …

2017年2月9日 · Mechanistically, we show that MARK4 binds to and phosphorylates the core components of the Hippo pathway, MST and SAV, and that MARK4, in a kinase‐dependent …

2017年10月24日 · 支架蛋白 SAV1 促进了这种激酶级联反应的激活，但分子机制仍然未知。 在这里，我们发现 SAV1 介导的对 PP2A 复合物 STRIPAKSLMAP 的抑制是 MST1/2 激活的关键 …

Hpo most closely resembles the pro-apoptotic mammalian sterile20 kinases 1 and 2 (Mst1 and 2), and Salvador (Sav) has a human orthologue hSav (also called hWW45). Here we show that …