
TDP-43 nuclear loss in FTD/ALS causes widespread alternative ...
2024年1月22日 · In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processing events remains unresolved. Here, we show that loss of TDP-43 causes widespread changes in alternat …
TDP是什么 CPU TDP和最大功率的关系(转) - 知乎专栏
TDP的英文全称是“Thermal Design Power”,中文直译是“散热设计功耗”。主要是提供给计算机系统厂商,散热片/风扇厂商,以及机箱厂商等等进行系统设计时使用的。
Motor neuron disease-associated loss of nuclear TDP-43 is linked ... - PNAS
2019年2月15日 · Here, we report that TDP-43 participates in the DNA damage response and its nuclear clearance in motor neurons causes DNA double-strand break repair defects in ALS. Our findings uncover a link between TDP-43 pathology and impaired DNA repair, and suggest potential avenues for DNA repair-targeted therapies for TDP-43–ALS.
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of ...
2022年2月23日 · Our findings, which demonstrate a genetic link between loss of nuclear TDP-43 function and disease, reveal the mechanism by which UNC13A variants exacerbate the effects of decreased TDP-43...
Stress-induced TDP-43 nuclear condensation causes splicing loss …
2024年7月23日 · Stress-induced nuclear condensation transiently inactivates TDP-43, leading to loss of interaction with its protein binding partners and loss of function in splicing. Splicing changes are especially prominent and persisting for STMN2 RNA, and STMN2 protein becomes rapidly depleted early during stress.
Endothelial TDP-43 depletion disrupts core blood–brain ... - Nature
2 天之前 · We found that TDP-43 CLIP targets were enriched in transcripts positively correlated with TDP-43 (Supplementary Fig. 11a; odds ratio 4.64, Fisher’s exact test, P < 0.0001). This is consistent ...
TDP-43 nuclear loss in FTD/ALS causes widespread alternative ...
2024年1月23日 · TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processing events remains unresolved. Here, we show that loss of TDP-43 causes widespread changes in alternative polyadenylation, impacting expression of disease-relevant genes (e.g., ELP1, NEFL, and TMEM106B) and providing evidence that alternative polyadenylation is a new ...
Molecular mechanisms linking loss of TDP-43 function to …
2024年11月1日 · Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by nuclear depletion and cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43). TDP-43 plays a key role in regulating the splicing of numerous genes, including TARDBP. This review aims to delineate two aspects of ALS/FTD pathogenesis associated with ...
Mis-spliced transcripts generate de novo proteins in TDP-43
2024年1月26日 · TDP-43 loss of function causes widespread cryptic splicing that can reduce the expression of mRNA transcripts. Here, we demonstrate that such mis-splicing can also generate de novo proteins from pathological transcripts. Our studies indicate that the inclusion of CEs in proteins can, in certain instances, alter their interacting protein partners.
Loss of TDP-43 function underlies hippocampal and cortical synaptic ...
2021年10月25日 · Our results show that loss of TDP-43 function underlies hippocampal and cortical synaptic degeneration in TDP-43 proteinopathies. Nuclear protein TAR DNA/RNA binding protein 43 (TDP-43) has...