TDP-43 nuclear loss in FTD/ALS causes widespread alternative ...
2024年1月22日 · In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a …
TDP是什么 CPU TDP和最大功率的关系（转） - 知乎专栏
TDP的英文全称是“Thermal Design Power”，中文直译是“散热设计功耗”。主要是提供给计算机系统厂商，散热片/风扇厂商，以及机箱厂商等等进行系统设计时使用的。
Motor neuron disease-associated loss of nuclear TDP-43 is linked ... - PNAS
2019年2月15日 · Here, we report that TDP-43 participates in the DNA damage response and its nuclear clearance in motor neurons causes DNA double-strand break repair defects in ALS. …
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of ...
2022年2月23日 · Our findings, which demonstrate a genetic link between loss of nuclear TDP-43 function and disease, reveal the mechanism by which UNC13A variants exacerbate the effects …
Stress-induced TDP-43 nuclear condensation causes splicing loss …
2024年7月23日 · Stress-induced nuclear condensation transiently inactivates TDP-43, leading to loss of interaction with its protein binding partners and loss of function in splicing. Splicing …
Endothelial TDP-43 depletion disrupts core blood–brain ... - Nature
3 天之前 · We found that TDP-43 CLIP targets were enriched in transcripts positively correlated with TDP-43 (Supplementary Fig. 11a; odds ratio 4.64, Fisher’s exact test, P < 0.0001). This is …
TDP-43 nuclear loss in FTD/ALS causes widespread alternative ...
2024年1月23日 · TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processing events remains unresolved. Here, we show that loss of TDP-43 causes widespread changes …
Molecular mechanisms linking loss of TDP-43 function to …
2024年11月1日 · Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by nuclear depletion and cytoplasmic aggregation of TAR DNA-binding protein …
Mis-spliced transcripts generate de novo proteins in TDP-43
2024年1月26日 · TDP-43 loss of function causes widespread cryptic splicing that can reduce the expression of mRNA transcripts. Here, we demonstrate that such mis-splicing can also …
Loss of TDP-43 function underlies hippocampal and cortical synaptic ...
2021年10月25日 · Our results show that loss of TDP-43 function underlies hippocampal and cortical synaptic degeneration in TDP-43 proteinopathies. Nuclear protein TAR DNA/RNA …