Apolipoprotein L1 (apoL1) is a minor apolipoprotein component of HDL cholesterol which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. …

2025年3月3日 · What is the APOL1 gene and how does it cause kidney disease? The APOL1 gene makes a protein in your immune system which is your body's cells and tissues that fight …

What is the APOL1 Gene? Apolipoprotein L1 (APOL1) is a gene located on chromosome 22, and has two coding variants, G1 and G2. APOL1 produces a protein that is a component of …

2024年2月8日 · Learn about APOL1-Mediated Kidney Disease (AMKD), its causes, symptoms, and treatments. Find information on genetic testing, complications, and management. AMKD …

2024年2月8日 · Two variant alleles of the gene apolipoprotein L1 (APOL1), known as risk variants (RVs), are a major contributor to kidney disease burden in those of African descent. The …

2024年4月20日 · APOL1 (OMIM 603743) encoding apolipoprotein L1 (apoL1) is an evolutionarily new gene found only in humans and some primates with key roles in innate immunity against …

2023年3月15日 · Persons with two apolipoprotein L1 (APOL1) variants (G1 or G2) are at higher risk for proteinuric chronic kidney disease (CKD), and those with CKD have an accelerated …

2024年10月26日 · Apolipoprotein L1 gene (APOL1) variants are risk factors for chronic kidney disease (CKD) among Black Americans. Data are sparse on the genetic epidemiology of CKD …

2013年12月5日 · In two studies, we examined the effects of variants in the gene encoding apolipoprotein L1 (APOL1) on the progression of chronic kidney disease. In the African …

Common variants in the APOL1 gene are associated with an increased risk of nondiabetic kidney disease in individuals of African ancestry. Mechanisms by which APOL1 variants mediate …