Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene. [5] [6] [7] ATGL catalyses the first reaction of lipolysis, [8] where triacylglycerols are hydrolysed to …

脂肪组织中有两种甘油三酯脂肪酶，脂肪组织甘油三酯脂肪酶（adipose triglyceride lipase，ATGL）和激素敏感脂肪酶（hormone-sensitive lipase，HSL）。 前者不需要激素激活即有活性，所以在基础脂解中非常重要，也是最主要的脂解酶。

Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis and produces FAs used for energy production. There is growing evidence that the products and ...

2024年8月14日 · Here, we show that zDHHC11 regulates LD catabolism by modifying adipose triacylglyceride lipase (ATGL), the rate-limiting enzyme of lipolysis, both in hepatocyte cultures and in mice. zDHHC11...

2021年10月24日 · 第一种是 甘油三酯脂肪酶(ATGL，由PNPLA2编码) ，是TAG水解为DAG（甘油二酯）的主要酶。全身和脂肪细胞特异性Pnpla2基因敲除小鼠均表现出基础状态和响应刺激下的脂解代谢显著减少，在人类脂肪细胞中敲除Pnpla2也观察到类似现象。

Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy production. There is growing evidence that the products and intermediates from lipolytic breakdown during the …

2022年6月8日 · Here we identified adipose triglyceride lipase (ATGL, also known as patatin-like phospholipase domain containing 2 (PNPLA2)) as a candidate biosynthetic enzyme for...

2024年3月21日 · Nature Communications - ATGL is a key enzyme in intracellular lipolysis. Here, the authors use deep mutational scanning to define the determinants of protein interaction between ATGL and its...

Adipose triglyceride lipase (ATGL) has been discovered 14 years ago and revised our view on intracellular triglyceride (TG) mobilization – a process termed lipolysis. ATGL initiates the hydrolysis of TGs to release fatty acids (FAs) that are crucial ...

脂肪组织甘油三酯水解酶(adipose triglyceride lipase,ATGL)是一种催化甘油三酯第一步水解的重要脂肪酶,在机体能量代谢调节中发挥重要作用.本文介绍了ATGL的基因和蛋白质结构,并详细综述了ATGL的功能调控和与其相关联疾病的研究进展,最后通过与激素敏感脂肪酶(HSL ...