CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a glycoprotein [5] found on the surface of many immune cells (white blood cells), including CD4 +, CD8 +, B lymphocytes and natural killer cells.

Nov 30, 2020 · The role of CD38 in immune cells ranges from modulating cell differentiation to effector functions during inflammation, where CD38 may regulate cell recruitment, cytokine release, and NAD availability.

Dec 24, 2024 · CD38 (CD38 Molecule) is a Protein Coding gene. Diseases associated with CD38 include Prolymphocytic Leukemia and Leukemia, Chronic Lymphocytic 2. Among its related pathways are NAD metabolism and Metabolism of water-soluble vitamins and cofactors.

Nov 30, 2020 · CD38 is a protein of 300 amino acids encoded by homologous genes located on chromosome 4 and 5 in humans and mice, respectively (15). Within the cell, CD38 is often found localized on the cell surface, but it can also be detected in intracellular compartments such as the endoplasmic reticulum, nuclear membrane and mitochondria (16 – 19).

Sep 15, 2003 · In chronic lymphocytic leukemia (CLL), expression of CD38 signifies a poor prognosis, though it does not correlate precisely with the presence of unmutated immunoglobulin variable region (IgV) genes and may vary during the course of the disease. 1 FIG1. Is it more than a prognostic marker?

Cluster of differentiation 38 (CD38) is a cell surface glycoprotein and multifunctional extracellular enzyme. As a NADase, CD38 produces adenosine through the adenosine energy pathway to cause immunosuppression. As a cell surface receptor, CD38 is necessary for immune cell activation and proliferation.

CD38 is a multifunctional protein widely expressed in cells from the immune system and as a soluble form in biological fluids. CD38 expression is up-regulated by an array of inflammatory mediators, and it is frequently used as a cell activation marker.

CD38 is a novel multifunctional protein that serves not only as an antigen but also as an enzyme. It catalyzes the metabolism of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate, two structurally and functionally distinct Ca2+ ...

Jul 23, 2024 · Targeting of CD38 has been posited as a potential therapeutic avenue for the treatment of immune-mediated conditions. A phase 2 study now reports promising safety, tolerability and intermediate...

In this paper, we reviewed the role and mechanism of CD38 + CD4 + T cells / CD38 + CD8 + T cells in cellular immunity and the effects of the CD38-NAD + axis on T cell activity.