NCI-H358 [H-358, H358] is an epithelial-like cell that was isolated from the bronchiole of a male patient with bronchioalveolar carcinoma. This cell line was deposited by AF Gazdar and JD Minna and can be used in cancer research.

Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

Oct 30, 2019 · In two KRAS G12C cell lines, NCI-H358 and MIA PaCa-2, AMG 510 almost completely inhibited p-ERK (IC 50 ≈ 0.03 μM) after a 2-h treatment and was 20-fold more potent than ARS-1620 (Extended Data...

Sep 5, 2024 · NCI-H358 is a human non-small cell lung cancer (NSCLC) cell line that is widely used in research related to KRAS gene mutations. The KRAS G12C mutation is relatively common in NSCLC and the NCI-H358 cell line harbors this mutation, which plays a critical role in tumor cell signaling and proliferation.

Oct 13, 2023 · We screened a panel of KRAS-G12C NSCLC cell lines and identified the ones that are inherently resistant or sensitive to sotorasib. We selected three cell lines, namely, H358, H23, and SW1573, based on their sensitivity to sotorasib in two-dimensional (2D) culture for further evaluation (Fig. 1A).

Nov 29, 2021 · A tool SHP2 inhibitor compound developed by Revolution Medicine is RMC-4550, which showed significant in vivo results when targeting KRAS G12C H358 and MIAPaCa-2 xenograft models both in terms of...

High molecular weight genomic DNA isolated from the NCI-H358; human bronchioalveolar carcinoma; non-small cell lung cancer cell line.

We conducted a saturation mutagenesis screen (Fig. 1A) in NCI-H358 (H358), an NSCLC KRAS G12C mutant cell line that carries one copy of KRAS WT (WT, wild-type) and one copy of KRAS G12C and is highly sensitive to KRAS G12C inhibitors (11, 13).

Jan 5, 2022 · Cell information for NCI-H358. Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Cell Line: NCI-H358, Established from primary bronchioalveolar carcinoma of the lung from a Caucasian male