研究主要集中在几个方面：直接抑制HK2的合成．这可以通过 RNA干扰 技术来沉寂 基因表达 实现；小分子药物包括Lonidamine可以直接抑制HK的活性．Bifonazol及Clotrimazole通过干扰HK与 线粒体 的结合起作用。

Hexokinase II, also known as Hexokinase B and HK2, is an enzyme which in humans is encoded by the HK2 gene on chromosome 2. [5] [6] Hexokinases phosphorylate glucose to produce glucose 6-phosphate, the first step in most glucose metabolism pathways. Hexokinase II is the predominant hexokinase form found in skeletal muscle.

Jan 31, 2018 · Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and suppressing glucokinase (GCK). This is exploited to...

Dec 25, 2024 · Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria.

Jun 6, 2022 · We discovered that the mitochondrial metabolic enzyme hexokinase 2 (HK2) localizes to the nucleus in leukaemic and normal haematopoietic stem cells. Overexpression of nuclear HK2 increases...

己糖激酶2（Hexokinase 2, HK2）是催化糖酵解途径中的第一步反应的关键代谢酶，将葡萄糖磷酸化为6-磷酸葡萄糖，主要定位在线粒体外膜上。 HK2在许多肿瘤中都呈现出高表达，在促进Warburg效应产生上起到重要作用。

星状细胞特异性或全身缺失HK2来抑制H3K18la可以减轻星状细胞的激活和肝纤维化。 2023年8月8日，伊利诺伊大学芝加哥分校的Nissim Hay团队在期刊Cell Metabolism（IF:29）发表文章《Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis》。 该研究利用CUT&Tag、 ChIP-qPCR 和 RNA-seq 等技术研究肝星状细胞活化和肝纤维化中己糖激酶和组蛋白乳酸化H3K18la的调控机制。

Oct 28, 2024 · Yan et al. report that fructose promotes the progression of colorectal cancer by inhibiting M1-like tumor-associated macrophage polarization. Specifically, fructose functions as a signaling molecule, enhancing the interaction between HK2 and ITPR3, which disrupts intracellular calcium signaling, thereby impeding M1-like macrophage polarization.

Dec 19, 2022 · By mining large datasets and generating transgenic tools, here we show that hexokinase 2 (HK2), the most active isozyme associated with mitochondrial membrane, is selectively expressed in...

己糖激酶 2 (hk2) 是参与糖酵解的关键酶，可将葡萄糖转化为葡萄糖-6-磷酸，在葡萄糖代谢中发挥重要作用。 hk2 可以介导糖酵解，这与炎症因子的释放有关。 hk2的过度表达会增加促炎细胞因子的产生，加剧炎症反应。

Mar 16, 2023 · Hexokinase 2 (HK2) plays a multifaceted role in the regulation of cellular activities. A new study by Hu et al.1 delineated a critical role of HK2 in governing glycolytic flux and mitochondrial activity, thereby modulating microglial functions in maladaptive inflammation in …

We recently discovered that HK2 facilitates autophagy in response to glucose deprivation (HK substrate deprivation) to protect cardiomyocytes, and suggest that HK2 functions as a molecular switch from glycolysis to autophagy to ensure cellular energy homeostasis under …

Jan 15, 2024 · Hexokinase 2 (HK2) is a crucial enzyme involved in glycolysis, which converts glucose into glucose-6-phosphate and plays a significant role in glucose metabolism. HK2 can mediate glycolysis, which is linked to the release of inflammatory factors.

Aug 8, 2023 · Using RNA-seq and CUT&Tag chromatin profiling, we found that induction of hexokinase 2 (HK2) expression in activated HSCs is required for induced gene expression by histone lactylation but not histone acetylation.

Mar 20, 2023 · 己糖激酶 2 （ Hexokinase 2, HK2 ）是催化糖酵解途径中的第一步反应的关键代谢酶，将葡萄糖磷酸化为 6-磷酸葡萄糖，主要定位在线粒体外膜上。 HK2 在许多肿瘤中都呈现出高表达，在促进 Warburg 效应产生上起到重要作用。

Jan 15, 2024 · Hexokinase 2 (HK2) is a crucial enzyme involved in glycolysis, which converts glucose into glucose-6-phosphate and plays a significant role in glucose metabolism. HK2 can mediate glycolysis, which is linked to the release of inflammatory factors. The over-expression of HK2 increases the production o …

Hexokinase-2 (HK2; EC:2.7.1.1) is one of four isozymes of hexokinase in mammalian metabolism that catalyze the first step of glucose metabolism, the conversion of glucose to glucose-6-phosphate (G6P): Glucose + MgATP → G6P + MgADP. That is, hexokinases interact with glucose and the magnesium Mg 2+ complex of ATP [1].

We show that hexokinase 2 (HK2) a metabolic enzyme fuelling cancer cell growth, is a transcriptional target of AHR as well as a modulator of its activity. Expression of HK2 is positively regulated by AHR upon exposure to agonists both in human cells and in mice lung tissues.

Oct 17, 2014 · Hexokinase catalyzes the phosphorylation of glucose, the rate-limiting first step of glycolysis. Hexokinase II (HK-II) is a predominant isoform in insulin-sensitive tissues such as heart,...

Feb 27, 2025 · Hong Kong authorities can only apply a new pricing model for the HK$2 (25 US cent) transport fare scheme by September of next year because they need time to organise updates, checks and tests ...