Apolipoprotein L1 (apoL1) is a minor apolipoprotein component of HDL cholesterol which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 is found in vascular endothelium, liver, heart, lung, placenta, [7] podocytes, proximal tubules, and arterial cells. [11]

2024年12月24日 · APOL1 (Apolipoprotein L1) is a Protein Coding gene. Diseases associated with APOL1 include Focal Segmental Glomerulosclerosis 4 and Glomerulonephritis. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins.

关于 apol1 Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,253,133-36,267,525 (from NCBI) This gene has 10 transcripts (splice variants), 509 orthologues, 6 paralogues and is associated with 2 phenotypes.

2022年2月25日 · Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were identified in 2010 and are relatively common among individuals of sub-Saharan African ancestry. Approximately 13%...

What is the APOL1 Gene? Apolipoprotein L1 (APOL1) is a gene located on chromosome 22, and has two coding variants, G1 and G2. APOL1 produces a protein that is a component of circulating high-density lipoprotein.

2021年7月27日 · Apolipoprotein L1 (ApoL1) is a circulating innate immunity protein protecting against trypanosome infection. However, two ApoL1 coding variants are associated with a highly...

2024年2月14日 · Apolipoprotein L1 (APOL1) circulates in the blood and protects humans against infection by African trypanosomes 1. APOL1 variants G1 (S342G, I384M) and G2 (∆N388:Y389) evolved...

2024年12月30日 · This review summarizes current understanding about the genetic, molecular, and clinical features of APOL1-associated FSGS and investigates new therapeutic options. It reveals how APOL1 mutations generate kidney injury through mechanisms such as podocyte dysfunction, mitochondrial impairment, and dysregulated inflammatory networks.

APOL1 is a member of the six-member APOL gene cluster located in human chromosome 22 (6 – 8). APOL1 has unique features compared with other APOL family proteins. APOL1 was initially identified in the human pancreas but is widely expressed, with the most abundant expression in the placenta, lungs, prostate, and spleen (9).

This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells.