PC-3 is a cell line initiated from a bone metastasis of a grade IV prostatic adenocarcinoma from a 62-year-old, White, male.

PC3 (PC-3) is a human prostate cancer cell line used in prostate cancer research and drug development. [1] PC3 cells are useful in investigating biochemical changes in advanced prostate cancer cells and in assessing their response to chemotherapeutic agents .

PC-3細胞可用於研究晚期前列腺癌細胞的生化變化，以及評估其對 化學治療劑 的反應。 PC-3細胞還用於研究表現出免疫反應的 哺乳動物 細胞中的 病毒 感染 [4]。 與具有中等轉移潛能的 DU145細胞 和具有低轉移潛能的LNCaP細胞相比，PC-3細胞具有較高的轉移潛能 [5]。 ^ Kaighn, ME; Narayan, KS; Ohnuki, Y; Lechner, JF; Jones, LW. Establishment and characterization of a human prostatic carcinoma cell line (PC-3).. Investigative urology. 1979-07, 17 (1): 16–23 [2020-01-13].

细胞描述：人前列腺癌细胞pc-3 来源于一名62 岁iv 级前列腺癌白人男性患者的骨髓 转移灶。 此细胞酸性磷酸酶（acid phosphatase ）和5-α- 睾丸激素还原酶

There are nearly 20 marker chromosomes commonly found in each cell; and normal N2, N3, N4, N5, N12, and N15 are not found. No normal Y chromosomes could be detected by Q-band analysis. The PC-3 was initiated from a bone metastasis of a grade IV prostatic adenocarcinoma from a 62-year-old male Caucasian.

PC-3: Background: Established from a grade 4 prostatic adenocarcinoma from a 62 year old male Caucasian. The cells grow in agar and produce tumours in nude mice. Exhibit low acid phosphatase and testosterone-5-alpha reductase activity. The Y chromosome could not be detected in this cell line by short tandem repeat (STR)-PCR analysis when tested ...

PC-3细胞具有快速的增殖能力和高度的转移潜能，在体内和体外都能形成肿瘤，因此被认为是一种高度致瘤的细胞系。 此外，PC-3细胞表达HLA A1和A9抗原，这些抗原可能与其免疫原性和肿瘤特异性有关。 另外，PC-3细胞的染色体数目为47至68条，具有一定的染色体异质性。 PC-3细胞的酸性磷酸酶活性和5-α-睾丸激素还原酶活性都低。 Yes, in semi-solid medium. nude mice inoculated subcutaneously with 1×10^7 cells. 适合于肿瘤学研究、前列腺癌疗效评估、药物筛选、基因表 …

2022年9月15日 · pc-3，人前列腺癌细胞，来源于一名62岁iv级前列腺癌白人男性患者的骨髓转移灶，在前列腺癌和毒理学研究中有应用。 pc-3贴壁生长，显微镜下呈上皮细胞样，该细胞在软琼脂中成簇生长，并可适应悬浮培养。pc-3适合作…

Prostatic small cell neuroendocrine carcinoma (SCNC) is a variant form of prostate cancer (PC). In contrast to adenocarcinoma, the tumor cells of SCNC do not form glands and are negative for AR and PSA. SCNC is extremely aggressive and does not respond to hormonal therapy.

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.