Primary cilia are known to be associated with pathogenesis of keratocystic odontogenic tumor and dentigenous cyst. A ciliopathy is classified as a disorder that results from aberrant form or function of primary cilia.

2023年4月18日 · Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate cell types, are essential for regulating signalling pathways during development and adult...

2006年8月4日 · The primary cilium has several characteristics that make it an ideal cellular location for sensing and transducing signals. It extends into the extracellular space, affording access to environmental signals.

2019年2月7日 · Primary cilia project in a single copy from the surface of most vertebrate cell types; they detect and transmit extracellular cues to regulate diverse cellular processes during development and to...

Learn how an organelle can be both a sensing organ and a transport machine. Eukaryotic flagella and cilia have long been recognized as organelles involved in motility, and their structure and...

Primary cilia are immotile, microtubule-based organelles extending from the surface of nearly every mammalian cell. Mechanical stimulation causes deflection of the primary cilium, initiating downstream signaling cascades to the rest of the cell.

This article looks mostly at the steps that have led to the primary cilium finding its place in our understanding of cell biology, developmental biology, and medical syndromes due to its aberrations. It is a personal account that stresses, if ...

5 天之前 · Primary cilium must be disassembled before mitosis to permit the MC to facilitate centrosome-mediated spindle organization and positioning. Serum starvation is commonly used to promote the formation of cilia in cultured cells and, consequently, the serum-starved cells gradually lose their cilia upon serum re-addition. ...

2020年12月21日 · A recent study reports the three-dimensional structure of a primary cilium with unprecedented clarity. The results highlight the architectural differences with motile cilia and provoke a reassessment of the relationship between the ciliary cytoskeleton and microtubule-based transport in cilia.

2023年1月23日 · We show that primary cilia are WNT-transducing organelles harboring cilia-localized LRP6 co-receptors that respond to and transmit WNT signals. We identify a ciliary targeting signal in LRP6 that it is essential for ciliogenesis, dissociating ciliary from …