2005年1月1日 · JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF …

JNKs activate apoptotic signaling by the upregulation pro-apoptotic genes via the transactivation of specific transcription factors or by directly modulating the activities of mitochondrial pro- and …

Dysregulated JNK signaling is now believed to contribute to many diseases involving neurodegeneration, chronic inflammation, birth defects, cancer and ischemia/reperfusion …

4 天之前 · There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active …

In this review, we will go over JNK signaling and focus on (1) the evidence of JNK activation in inflamed joints, (2) how the activation of the JNK signaling pathway is immunologically …

2001年11月20日 · The activation of Jnk has been implicated in a number of important physiological processes, from embryonic morphogenesis to cell survival and apoptosis.

2024年10月7日 · JNK signaling, an integral component of the Mitogen-Activated Protein Kinase (MAPK) pathways, plays crucial roles in various cellular processes. Understanding this …

2016年1月11日 · Simplified diagram showing mechanisms involved in activation of the JNK pathway. Different stress conditions might activate JNK signaling via scaffold proteins. UPR …

These authors demonstrated that the early transient phase of JNK activation (<1 h) promotes cell survival, whereas the later and more sustained phase of JNK activation (1–6 h) mediates …

2008年10月20日 · JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the …