By activating and inhibiting other small molecules in this way, JNK activity regulates several important cellular functions including cell growth, differentiation, survival and apoptosis. JNK1 …

JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and …

2005年1月1日 · Emerging evidence suggests that JNK may function as a modulator to “break the brake” on apoptosis, rather as a genetic component of the apoptotic machinery to induce …

2016年7月27日 · The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase (MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and …

2007年8月1日 · JNK/SAPKs have since been characterized to be involved in proliferation, apoptosis, motility, metabolism and DNA repair. Dysregulated JNK signaling is now believed to …

2000年4月15日 · As its full name suggests, Jun N-terminal kinase (JNK, pronounced ‘junk’) is an enzyme that phosphorylates the amino-terminal domain of the Jun transcription factors. JNK is …

c-Jun N-terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with …

JNKs also regulate important physiological processes, including neuronal functions, immunological actions, and embryonic development, via their impact on gene expression, …

2014年4月17日 · A major breakthrough in understanding nuclear JNK function emerged from recent studies showing that JNK directly targets chromatin modifiers, driving histone …

2016年1月11日 · JNK’s, particularly JNK3, not only enhance Aβ production, moreover it plays a key role in the maturation and development of neurofibrillary tangles. This review aims to …