- Adipose triglyceride lipase
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Adipose triglyceride lipase - Wikipedia
Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene. ATGL catalyses the first reaction of lipolysis, where triacylglycerols are hydrolysed to diacylglycerols. 展开
ATGL has very high substrate specificity for triacylglycerols. It contains a catalytic dyad using serine-aspartic acid. 展开
Defects in ATGL can cause problems in lipolysis, leading to neutral lipid storage disease. As triacylglycerols are not hydrolysed to … 展开
There must be mechanisms set to maintain the balance between energy storage, and energy release; a dysregulation in the equilibrium result in metabolic disorder, a … 展开
• Human PNPLA2 genome location and PNPLA2 gene details page in the UCSC Genome Browser. 展开
ATGL catalyses the first reaction of lipolysis. It hydrolysis triacylglycerols to diacylglycerols by attacking the fatty acid attached to carbon-3 of glycerol.
ATGL acts as a control mechanism of lipolysis, as variations in diacylglycerol concentration impact … 展开• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". … 展开
CC-BY-SA 许可证中的维基百科文本 Adipose Triglyceride Lipase Regulation: An Overview - PMC
Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis and produces FAs used for energy …
ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty ...
2022年6月8日 · Here we identified adipose triglyceride lipase (ATGL, also known as patatin-like phospholipase domain containing 2 (PNPLA2)) as a candidate biosynthetic enzyme for …
Adipose Triglyceride Lipase Regulation: An Overview - PubMed
Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy …
- 作者: Ines Katrin Cerk, Lisa Wechselberger, Monika Oberer
- Publish Year: 2017
Of mice and men: The physiological role of adipose …
ATGL initiates the hydrolysis of TGs to release fatty acids (FAs) that are crucial energy substrates, precursors for the synthesis of membrane lipids, and ligands of nuclear receptors. Thus, ATGL is a key enzyme in whole-body energy …
The Minimal Domain of Adipose Triglyceride Lipase (ATGL) Ranges …
Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of lipolysis. ATGL specifically hydrolyzes triacylglycerols (TGs), thereby generating diacylglycerols and free fatty acids. …
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The role of adipose triglyceride lipase in lipid and …
2019年11月22日 · The discovery of adipose triglyceride lipase (ATGL) as a triglyceride lipase provided a heightened understanding of the mechanisms governing mobilization of fat reserves from adipose tissue. ATGL catalyses …
Adipose Triglyceride Lipase - an overview | ScienceDirect Topics
The enzyme adipose triglyceride lipase (ATGL) catalyzes the initial and often rate-limiting step of intracellular lipolysis [11]. This involves the conversion of a triacylglycerol molecule to …
Zinc-Mediated Deacetylation of FXR Activates the ATGL
3 天之前 · Adipose triglyceride lipase (ATGL), the rate-limiting enzyme for TG hydrolysis, is another critical regulator of lipid turnover [12]. Loss of ATGL function leads to steatosis, while …
ATGL: Key Insights Into Lipid Metabolism and Regulation
2025年3月10日 · ATGL serves as a pivotal enzyme in the balance of lipid synthesis and degradation, influencing cellular energy stores and systemic metabolic health. By liberating …
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