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c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 … 展开
Exploring the function of the JNK (c-Jun N-terminal kinase) …
JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and …
- 作者: Clare Davies, Cathy Tournier
- Publish Year: 2012
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Role of JNK activation in apoptosis: A double-edged …
2005年1月1日 · Emerging evidence suggests that JNK may function as a modulator to “break the brake” on apoptosis, rather as a genetic component of …
- 作者: Jing Liu, Anning Lin
- Publish Year: 2005
JNK Signaling: Regulation and Functions Based on Complex
2016年7月27日 · The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase (MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and …
- 作者: András Zeke, Mariya Misheva, Attila Reményi, Marie A. Bogoyevitch
- Publish Year: 2016
The c-jun kinase/stress-activated pathway: Regulation, function …
2007年8月1日 · JNK/SAPKs have since been characterized to be involved in proliferation, apoptosis, motility, metabolism and DNA repair. Dysregulated JNK signaling is now believed to …
- 作者: Gary L. Johnson, Kazuhiro Nakamura
- Publish Year: 2007
JNK: Current Biology - Cell Press
2000年4月15日 · As its full name suggests, Jun N-terminal kinase (JNK, pronounced ‘junk’) is an enzyme that phosphorylates the amino-terminal domain of the Jun transcription factors. JNK is a serine/threonine kinase, a member of …
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JNK signaling in cancer cell survival - PubMed
c-Jun N-terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with …
JNK Signaling: Regulation and Functions Based on …
JNKs also regulate important physiological processes, including neuronal functions, immunological actions, and embryonic development, via their impact on gene expression, cytoskeletal protein dynamics, and cell death/survival …
Nuclear and cytosolic JNK signalling in neurons - Nature
2014年4月17日 · A major breakthrough in understanding nuclear JNK function emerged from recent studies showing that JNK directly targets chromatin modifiers, driving histone …
Frontiers | c-Jun N-terminal Kinase (JNK) …
2016年1月11日 · JNK’s, particularly JNK3, not only enhance Aβ production, moreover it plays a key role in the maturation and development of neurofibrillary tangles. This review aims to …
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