- Adipose triglyceride lipase
- 根据 4 个来源
- 查看更多前往 Wikipedia 查看全部内容
Adipose triglyceride lipase - Wikipedia
Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene. ATGL catalyses the first reaction of lipolysis, where triacylglycerols are hydrolysed to diacylglycerols. 展开
ATGL has very high substrate specificity for triacylglycerols. It contains a catalytic dyad using serine-aspartic acid. 展开
Defects in ATGL can cause problems in lipolysis, leading to neutral lipid storage disease. As triacylglycerols are not hydrolysed to … 展开
There must be mechanisms set to maintain the balance between energy storage, and energy release; a dysregulation in the equilibrium result in metabolic disorder, a … 展开
• Human PNPLA2 genome location and PNPLA2 gene details page in the UCSC Genome Browser. 展开
ATGL catalyses the first reaction of lipolysis. It hydrolysis triacylglycerols to diacylglycerols by attacking the fatty acid attached to carbon-3 of glycerol.
ATGL acts as a control mechanism of lipolysis, as variations in diacylglycerol concentration impact … 展开• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". … 展开
CC-BY-SA 许可证中的维基百科文本 Adipose Triglyceride Lipase Regulation: An Overview - PMC
The dissociation of CGI-58 from Plin1 enables its interaction with ATGL, which activates ATGL’s TG hydrolyzing activity. In both, basal and stimulated state of lipolysis, ATGL can be inhibited …
Adipose Triglyceride Lipase Regulation: An Overview - PubMed
Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy …
- 作者: Ines Katrin Cerk, Lisa Wechselberger, Monika Oberer
- Publish Year: 2017
S-acylation of ATGL is required for lipid droplet homoeostasis in ...
2024年8月14日 · Our study focused on hepatocytes, but a previous proteomic study using adipocytes identified ATGL as a potentially S-acylated protein, although the sites and, more …
Mutational scanning pinpoints distinct binding sites of key ATGL ...
2024年3月21日 · Here, the authors use deep mutational scanning to define the determinants of protein interaction between ATGL and its regulatory partners, gaining insights into lipolysis …
Adipose Triglyceride Lipase - an overview | ScienceDirect Topics
The G0/G1 switch gene-2 (G0S2) encodes a protein discovered as a selective controller of ATGL, lowering its action in both cells and mice. G0S2 is primarily expressed in adipose tissue and …
- 其他用户还问了以下问题
Of mice and men: The physiological role of adipose …
Recently, it has been shown that ATGL is profoundly inhibited by a small protein called hypoxia-inducible LD-associated protein (HILPDA, also known as hypoxia inducible gene 2, HIG2) which directly binds to the patatin domain of ATGL …
Adipose triglyceride lipase suppresses noncanonical ... - Nature
2024年2月27日 · Nature Chemical Biology - Adipose triglyceride lipase (ATGL), an enzyme in fatty acid metabolism, was identified as a negative regulator of the noncanonical …
Adipose triglyceride lipase activity regulates cancer cell ...
2020年9月1日 · (A) Protein expression levels of ATGL, HSL, and MGL in shControl/shATGL cancer cell lines were analyzed by western blot analysis. GAPDH was used as housekeeping …
N-end Rule-Mediated Proteasomal Degradation of ATGL …
2023年2月1日 · The N-end rule-resistant ATGL(F2A) mutant, in which the N-terminal phenylalanine (F) of ATGL is substituted by alanine (A), has increased protein stability and …
- 某些结果已被删除
