2025年3月10日 · Adipose triglyceride lipase (ATGL) plays a vital role in lipid metabolism, breaking down stored fats into free fatty acids and glycerol. This process is crucial for energy …

ATGL is regulated by insulin, and is similar to structure with adiponutrin, a protein that is regulated by nutrition. When there is a lack of insulin, there is an increased expression of the ATGL protein.

2019年11月22日 · The discovery of ATGL as an intracellular lipase has been key not only to understanding lipolysis regulation in multiple tissues, but also the integration between glucose …

2006年1月1日 · Adipose triglyceride lipase (ATGL) is a recently described adipose-enriched protein with triglyceride-specific lipase activity. ATGL shares the greatest sequence homology …

2006年12月1日 · First published January 11, 2007; doi:10.1152/ajpgi.00554.2006.—Triacylglycerol (TAG) stored in ad-ipose tissue can be rapidly …

2016年9月22日 · Taken together, we uncover a hitherto unknown posttranscriptional regulation of ATGL in hepatocytes where COP1 directly binds to ATGL via the VP motif and serves as the …

2008年5月1日 · ATGL small interfering RNA in myotubes reduced TG hydrolase activity and increased TG content, whereas ATGL overexpression induced the reciprocal response, …

Several additional studies have addressed the regulation of ATGL expression, and it has been found that in humans, ATGL protein is upregulated by fasting (Nielsen et al. 2011), while in …

2018年1月1日 · Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for …

Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy production.