Neurotrophin binding to p75NTR activates a JNK signaling pathway causing apoptosis of developing neurons. JNK, through a series of intermediates, activates p53 and p53 activates …

For example, genetic studies have demonstrated that the removal of specific Jnk genes can reduce neuronal death associated with cerebral ischaemia. As such, targeting JNK signalling …

2016年7月27日 · We analyzed almost 100 of these target proteins in detail within a framework of their classification based on their regulation by JNKs.

JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is …

4 天之前 · The c-Jun N-terminal kinase (JNK) pathway is one of the major signaling cassettes of the mitogen-activated protein kinase (MAPK) signaling pathway. It functions in the control of a …

Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer. The pro-survival JNK oncoprotein …

Through its interaction with a diverse set of signaling proteins and adaptors, JNKs regulate cell proliferation, invasive migration, therapy resistance, and programmed cell death.

Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinases (MAPKs) have important roles in the signalling mechanisms that orchestrate cellular responses to many types …

2024年10月7日 · JNK signaling, an integral component of the Mitogen-Activated Protein Kinase (MAPK) pathways, plays crucial roles in various cellular processes. Understanding this …

2014年4月17日 · JNKs are components of a classical mitogen-activated protein kinase (MAPK) signalling cascade (Fig. 1a) that serves to filter noise and allow signal amplification while …