E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells.

(A) The E2F family is divided into at least four subgroups defined by their regulation by pocket proteins and chromatin modifiers, and by their physiological function (i.e. activation or repression). See text for details.

Among E2F genes, the E2F3 and E2F7 loci can undergo two alternative splicing events to encode four protein isoforms: E2F3a, E2F3b, E2F7a, and E2F7b (29–31). The E2F family can be broadly divided into two categories, typical E2Fs (E2F1-6) and atypical E2Fs (E2F7-8), based on their unique structural characteristics (32, 33).

2020年3月5日 · Here we find that a mammalian circadian rhythm component, Cryptochrome 2 (CRY2), regulates E2F family members. Furthermore, CRY1 and CRY2 cooperate with the E3 ligase complex SKP-CULLIN-FBXL3...

2004年12月8日 · The E2F transcription factors are key regulators of cell cycle progression and the E2F field has made rapid advances since its advent in 1986. Yet, while our understanding of the roles and functions of the E2F family has made enormous progress, with each discovery new questions arise.

E2F is a heterodimer composed of two partners, such as E2F1 and DP1. Although E2F1 can bind DNA as a homodimer and increase promoter activity, optimal DNA-binding and transcriptional activity occurs in the heterodimeric form.

E2F refers to a group of genes that encode a family of transcription factors that regulate the cell cycle, apoptosis, differentiation and stress responses (Muller & Helin, 2000). In the physiological state, the retinoblastoma (Rb) tumor suppressor protein binds and regulates E2F proteins (Dick, Goodrich, Sage, & Dyson, 2018).

Atypical E2F proteins represent an evolutionarily conserved branch of the E2F TFs family, in which the presence of a duplicated DBD provides these new E2F players the unique ability to bind DNA in a DP-independent manner.

2002年1月1日 · In the past decade, E2F activity has been shown to arise from the concerted action of a family of proteins that have distinct biological properties from one another. In this review, we discuss...

Since the discovery almost fifteen years ago that E2F transcription factors are key targets of the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the control of transcription, cell cycle and apoptosis.