2023年12月19日 · Our findings suggest that berberine improves stroke outcomes by modulating the gut microbiota. Specifically, after MCAO/R mice were given berberine, the beneficial bacteria producing butyric acid increased significantly, and the …

2021年11月26日 · By specifically deleting MEGF10 and MERTK phagocytic receptors, we determined that inhibiting phagocytosis of microglia/macrophages or astrocytes in ischemic stroke improved neurobehavioral...

2021年1月26日 · Our data showed that nicorandil treatment could decrease brain damage, improve learning and memory, and increase SYP、GAP43 and NeuN level. Taken together, we propose that nicorandil, as an opener of the KATP channel, provides a neuroprotective role in MCAO by promoting synaptic connections.

2023年8月17日 · 为了检测颅骨骨髓对脑损伤反应的参与，研究中团队使用了中大脑动脉闭塞(mcao)小鼠作为研究中风的模型（图1a）。 在 MCAo 中，小鼠首先进行颈部切口以暴露颈动脉，然后再闭塞大脑中动脉（图 1 A）。

2023年8月9日 · Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype.

They found that the cytoplasm of microglia/macrophages contained synaptic elements, including presynaptic (synaptophysin, SYP) and postsynaptic (Homer-1) proteins, and that these cells engulfed both inhibitory and excitatory synapses in an MCAO model of ischemic stroke.

2023年2月2日 · Our data indicated that CRS combined with MCAO could induce depression-like and anxiety-like behaviors, which led to neuronal damage, apoptosis, and cellular loss in the left parietal cortex and left hippocampus. Furthermore, CRS combined with MCAO decreased synaptic plasticity in the parietal cortex and left hippocampus.

2021年1月26日 · Our data showed that nicorandil treatment could decrease brain damage, improve learning and memory, and increase SYP、GAP43 and NeuN level. Taken together, we propose that nicorandil, as an opener of the KATP channel, provides a neuroprotective role in MCAO by promoting synaptic connections.

Minocycline prevents cognitive deficits via inhibiting mTOR signaling and enhancing the autophagy process, and promoting the expression of pre- and postsynaptic proteins (synaptophysin and PSD-95) in the brain of the MCAO stroke rats.

Invitrogen Anti-Synaptophysin Monoclonal (SP11), Catalog # MA5-14532. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody reacts with Human, Mouse, Rat samples. Supplied as 500 µL unpurified antibody.