Co-101244 | C21H27NO3 | CID 6918409 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Co 101244 hydrochloride | C21H28ClNO3 | CID 6918426 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist [1]. Co 101244 effectively reduces NMDA-evoked Ca 2+ elevations while enhancing neuroprotection [1]. MCE has not independently confirmed the accuracy of these methods. They …

Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) 是一种含有 NR2B 的 NMDA 受体拮抗剂。 属性

Co 101244 hydrochloride is a novel, potent and selective antagonist of GluN2B (formally NR2B)-containing NMDA receptors (IC 50 values are 0.043, > 100 and > 100 μ M for GluN1A/2B (NR1A/2B), GluN1A/2A (NR1A/2A) and GluN1A/2C (NR1A/2C) subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro.

Co 101244 hydrochloride 是一种特异性NR2B亚基的NMDA受体拮抗剂，可通过抑制NMDA受体介导的兴奋性神经传导，调控神经信号通路。 在体外和体内实验中，该化合物已被验证能够影响突触可塑性和神经元活性。

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