We described the clinical features and outcomes for 63 adult patients with acute myeloid leukemia (AML) with a reciprocal translocation involving the 11q23 locus (MLL) who were treated at …

2003年8月1日 · MLL is a developmental regulator and is structurally altered in leukemia associated translocations that show an abnormality at band 11q23. The MLL gene on 11q23 is …

2025年2月12日 · AML with 11q23 abnormalities comprises 5% to 6% of cases of AML and is typically associated with monocytic features. This type of AML is more common in children.

2003年10月1日 · In an unselected series of 1897 AML cases, 54 patients with an 11q23/ MLL rearrangement were identified, resulting in an incidence of 2.8%. The incidence of AML with …

Patients with t (9;11)), t (6;11), or other 11q23 balanced translocations [t (11;v) (q23;v)] presented at a younger age and with higher percentage of bone marrow blasts. Unbalanced 11q23 …

Aim: To detect the frequency, diagnostic and prognostic significance of 11q23/MLL rearrangements and to determine the chromosomes that are most frequently involved in …

KMT2A (alias: mixed-lineage leukemia [MLL]) gene mapping on chromosome 11q23 encodes the lysine-specific histone N-methyltransferase 2A and promotes transcription by inducing an …

The MLL gene, located at chromosome 11, band q23, is frequently disrupted by a variety of chromosomal rearrangements that occur in acute lymphoblastic leukemias and in a subset of …

11q23 translocations (t (11q23)) are recurring cytogenetic abnormalities in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia, involving the same gene, ALL1 (or MLL). …

2022年11月15日 · Background: Balanced rearrangements involving the KMT2A gene (KMT2A r) are recurrent cytogenetic abnormalities in AML, although globally they are present in only 3 …

2021年9月29日 · Chromosomal translocations involving 11q23 where the lysine methyltransferase 2a gene (KMT2A) is located cause acute leukemias with high rates of resistance and relapse …

The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in chromosomal translocations in a subtype of acute leukemia, which represents approximately …

2020年11月1日 · Structural abnormalities involving the long arm of chromosome 11, region 2, band 3 (11q23), are cytogenetic changes consistently seen in hematopoietic malignancies, …

2004年2月1日 · There is strong molecular evidence that 11q23 abnormalities in infants with ALL occur in utero. The 11q23 band/MLL gene has an important role in normal hematopoietic …

Rearrangements of the MLL gene located at 11q23 are common chromosomal abnormalities associated with acute leukemia (AL), especially infant and secondary leukemia after previous …

2009年9月17日 · Translocations involving chromosome 11q23 frequently occur in pediatric acute myeloid leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene …

11q23 translocations (t(11q23)) are recurring cytogenetic abnormalities in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia, involving the same gene, ALL1 (or MLL).

2012年11月8日 · Unbalanced 11q23 abnormalities were commonly associated with deletions of chromosomes 5q, 7q and/or complex karyotypes.

2015年4月8日 · Translocations involving the 11q23, a relatively common genetic abnormality in acute leukemia, have been seldom reported in CML. In this study, we explored the prevalence …

Unbalanced 11q23 abnormalities were commonly associated with deletions of chromosomes 5q, 7q and/or complex karyotypes.