CCT129202 is an aurora kinase inhibitor with IC50 s of 42, 198, and 227 nM for aurora A, B and C, respectively. CCT129202 causes the accumulation of human tumor cells with z4N DNA content, leading to apoptosis. CCT129202 is found to induce apoptosis with GI 50 values that ranges between 0.08 and 1.7 μM.

Cct-129202 | C23H25ClN8OS | CID 16202152 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

CCT129202 is an aurora kinase inhibitor with IC50 s of 42, 198, and 227 nM for aurora A, B and C, respectively. CCT129202 causes the accumulation of human tumor cells with z4N DNA content, leading to apoptosis. CCT129202 is found to induce apoptosis with GI 50 values that ranges between 0.08 and 1.7 μM.

The compound CCT129202 is a new and selective inhibitor of Aurora kinase A and B that decreases the viability of a variety of human tumor cell lines. The effect of Aurora kinase inhibition was assessed in the HMC-1⁵⁶⁰,⁸¹⁶ line in order to find a suitable tool for mastocytosis treatment.

2007年11月1日 · We developed and characterised the mechanism of action of CCT129202, a small molecule inhibitor of Aurora kinase activity. CCT129202 inhibits Aurora kinases with an IC50 of 50 nM, inhibits growth of a panel of human tumour cell lines with GI50 between 0.1 μM - 1 μM and induced accumulation of tumour cells with 4N DNA content.

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CCT-129202是由Cancer Research UK研发的一种小分子药物，是一种丝氨酸/苏氨酸蛋白激酶Aurora家族抑制剂。 目前该药物最高研发阶段为无进展，用于治疗肿瘤。

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