15-Hydroxyeicosatetraenoic acid (also termed 15-HETE, 15(S)-HETE, and 15S-HETE) is an eicosanoid, i.e. a metabolite of arachidonic acid. Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE).

5-oxo-ete是通过选择性酶将5-脂氧合酶产物5s-hete氧化而合成的，5-羟基类花生酸脱氢酶。 它的作用是由选择性OXE受体介导的，该受体在嗜酸性粒细胞上高度表达，表明它在嗜酸性疾病如哮喘中可能很重要。

15S‑HETE and 11R-HETE are substrates for 15‑hydroxyprostaglandin dehydrogenase, the enzyme catalysing the first step of prostaglandin catabolism, to yield 15-oxo-ETE and 11‑oxo‑ETE, respectively, which mediate anti-proliferative properties in endothelial cells. They can also form CoA esters, which can undergo up to four double bond ...

eet是花生四烯酸（aa）的20碳代谢产物，具有多种生理作用。它们是通过细胞色素p450环氧合酶途径从aa产生的。产生四种不同的异构体：5，6-eet、8，9-eet、11，12-eet和14，15-eet。在心脏中，eet在缺血/再灌注损伤中发挥心脏保护作用。eet被归类为edhf。

在内皮细胞和上皮细胞中，低剂量阿司匹林诱导的cox-2乙酰化会使其功能发生改变，可以将花生四烯酸转化为15-r-羟基二十碳四烯酸（15-r-hete）。 然后再通过5-脂氧合酶（5-LOX）的作用，在单核细胞和白细胞中代谢为差向脂氧素（epi-LX），也称为阿司匹林触发脂氧 ...

The biologically active isomer, 15(S)-HETE, the product of 15-lipoxygenase, is a powerful mediator of inflammation and the effector of a large number of bioactions. 15(R,S)-HETE was found in native hemozoin (0.24 millimole/mole hemozoin heme), in supernatants of hemozoin-fed monocytes (87 nMol) and in hemozoin-fed monocytes (9.6 microMol).

- (±)15-HETE是一种脂质类化合物，通常为无色或浅黄色油状液体。 - 可溶于有机溶剂如乙醚、乙醇等，不溶于水。 - 具有生物活性，在生物体内扮演重要的信号传递分子角色。 - 作为生物学研究中的生理活性物质，可用于了解细胞信号传导途径、炎症反应等生物过程。 - (±)15-HETE可从芥酸或亚麻酸等Omega-6系列脂肪酸通过细胞氧化酶酶类（lipoxygenase）的催化作用制备而来。 - (±)15-HETE是一种生物活性分子，应当小心处理，并遵守相关化学品安全操作规范。 - 尚无相 …

2023年3月29日 · Pharmacological inhibition of Alox15 can prevent ferroptosis and attenuate heart damage. A, 15-HETE and 15-HpETE levels in the heart tissues of mice treated with vehicle or ML351 24 hours after I/R surgery. B, Serum lactate dehydrogenase (LDH) levels in the heart tissues of mice treated with ML351 or vehicle 24 hours I/R surgery.

已知15-脂氧合酶/ 15-羟基二十碳四烯酸（15-lo / 15-hete）调节缺氧后肺血管内侧肥大，内膜内皮细胞迁移和血管生成。 但是，尚不清楚15-HETE是否会影响肺动脉壁的外膜。

15 (S)-HETE is an endogenous metabolite present in Urine that can be used for the research of Zellweger Syndrome [1] [2]. Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome.