Human 15S-lipoxygenase-2 (15-LOX-2) is a recently identified lipoxygenase that has approximately 40% sequence identity to the known human 5S-, 12S-, and 15S-lipoxygenases. …

15-脂氧合酶 (15-LOX)是催化不饱和脂肪酸代谢的关键酶之一.人类中存有两型15-LOX:15-LOX-1和15-LOX-2,两者在催化性质,组织分布及肿瘤生物学功能上有所差异.近年来大量研究发现15-LOX …

2014年3月3日 · We report here the crystal structure of human 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed …

2014年8月11日 · This study employs high throughput screening to identify two novel, specific 15­LOX­2 inhibitors. MLS000545091 is a mixed-type inhibitor of 15-LOX-2 with a Ki of 0.9+/−0.4 …

2024年12月19日 · The human 15-lipoxygenase-2 (h15-LOX-2) catalyzes mainly the regio- and stereospecific oxygenation of arachidonate to its corresponding hydroperoxide (15 (S) …

2006年4月1日 · 15-lipoxygenase (15-LOX) belongs to the structurally and functionally related nonheme iron dioxygenases family. It has two isoforms, type-1 (leukocyte type) and type-2 …

The human 15-lipoxygenase-2 (h15-LOX-2) catalyzes mainly the regio- and stereospecific oxygenation of arachidonate to its corresponding hydroperoxide (15­(S)-HpETE). h15-LOX-2 is …

2023年12月5日 · Dual-acting COX-2/5-LOX inhibitors may treat cancer by suppressing COX-2 and 5-LOX enzymes. 15-LOX inhibitors lack some of the side effects of 5-LOX inhibitors. …

在这里，我们描述了 COX-2、15-LOX 和 PPARγ 在癌症和代谢紊乱并发症中的作用，强调了设计多靶点定向配体 (MTDL) 以改变其活性的价值，并总结了有关基本原理的现有文献以及这些配 …

2018年6月7日 · 15-LOX can be subclassified according to specificity of tissue distribution and enzymatic characteristics into 15-LOX-1 and 15-LOX-2. 15-LOX-1 catalyzes deoxygenation of …