2′-Deoxy-2′- [18 F]fluoro-5-ethyl-1-β- d -arabinofuranosyluracil ( [18 F]FEAU) is a promising radiolabeled nucleoside designed to monitor Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene expression with positron emission tomography (PET).

Radiochemical purity was >99%, and specific activity was >1800 mCi/μmol at EOS. Synthesis time was 95-100 min from EOB. This direct fluorination is a novel method for the synthesis of 18 F-FMAU, and the method should be suitable to produce other 5-substituted pyrimidine analogues, including 18 F-FEAU, 18 F-FIAU, 18 F-FFAU, 18 F-FCAU, and 18 F ...

2'-deoxy-2'-[(18)F]fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil ([(18)F]FEAU) is a promising radiolabeled nucleoside designed to monitor Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene expression with positron emission tomography (PET).

2011年7月1日 · The efficient automated syntheses of [18 F]FAU, [18 F]FEAU, [18 F]FFAU, [18 F]FCAU, [18 F]FBAU and [18 F]FIAU have been achieved with reasonable yields and high purity using a multistep one-pot strategy. The synthetic time has been reduced, and the reaction procedures have been significantly simplified.

2007年3月8日 · Non-invasive imaging of transgene expression requires the appropriate combination of a reporter gene and a reporter probe. [18 F]FEAU positron emission tomography (PET) is used for the...

2009年10月7日 · We report here a fully automated synthesis of [18 F]-FEAU and [18 F]-FMAU on a prototype dual reactor module TRACERlab FX FN. The synthesis was performed by using a computer-programmed standard operating procedure, and the product was purified on a semipreparative high-performance liquid chromatography (HPLC) integrated with the synthesis ...

2012年11月1日 · Using the microwave-driven heating approach, [18 F]-FIAU, [18 F]-FMAU and [18 F]-FEAU have been successfully synthesized within 120 min, affording a radiochemical yield of 19%–27% (decay corrected) at a specific activity of > 22 MBq/nmol (595 Ci/mmol).

The improved radiosyntheses of [(18)F]FAU, [(18)F]FEAU, [(18)F]FFAU, [(18)F]FCAU, [(18)F]FBAU and [(18)F]FIAU have been achieved with reasonable yields and high purity using a multistep one-pot method. The synthetic time has been reduced, and the reaction procedures have been significantly simplifie …

This study demonstrated the versatile use of the ELIXYS fully automated radiosynthesizer to adapt and produce 8 different (18)F-labeled PET tracers of varying complexity.

Non-invasive imaging of transgene expression requires the appropriate combination of a reporter gene and a reporter probe. [18F]FEAU positron emission tomography (PET) is used for the assessment...