Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. [1] It is used to treat organophosphate poisoning [2] in conjunction with atropine and either diazepam or midazolam. It is a white solid.

pralidoxime decreases levels of benperidol by inhibition of GI absorption. Applies only to oral form of both agents.

Available in the United States as PROTOPAM Chloride for Injection (PROTOPAM), pralidoxime chloride is frequently referred to as 2-PAM Chloride. Pralidoxime chloride occurs as an odorless,...

What Is Pralidoxime and How Does It Work? Pralidoxime is an antidote used for reversing organophosphate poisoning and acetylcholinesterase inhibitor toxicity (Neostigmine, Pyridostigmine). Pralidoxime is available under the following different brand names: Protopam, 2PAM Antidote, Pralidoxime Auto Injector. What Are Dosages of Pralidoxime?

2-PAM (2-pyridine aldoxime methyl chloride) — also called pralidoxime — is one of a class of chemicals, called oximes that reverse the binding of cholinesterase inhibitors with acetylcholinesterase. There is some controversy about the efficacy of …

2025年1月7日 · 2 Pam chloride is used for an antidote: In the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis. The principal indications for the use of 2 Pam chloride are muscle weakness and respiratory depression. In severe poisoning, respiratory depression may be due to muscle weakness.

2005年6月13日 · Pralidoxime is a cholinesterase reactivator used to treat organophosphate poisoning. Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme.

2024年3月25日 · Pralidoxime chloride is a cholinesterase reactivator. Chemical Name: 2-formyl-1 methylpyridinium chloride oxime (pyridine-2-aldoxime methochloride). Also referred to as 2-PAM Chloride. Structural Formula:

Pralidoxime chloride (2-PAM) is the only oxime currently approved for use in the United States. Oximes differ in their effectiveness against specific agents, recommended doses, and side effect profiles. Oximes commonly used in other countries include obidoxime, trimedoxime, and HI-6.

2024年5月16日 · Chemical name: 2-formyl-1-methylpyridinium chloride oxime. Available in the United States as PROTOPAM Chloride for Injection (PROTOPAM Chloride), pralidoxime chloride is frequently referred to as 2-PAM Chloride.