2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX - Caspase 3 …

Since 2000, when 2BP was recognized as an inhibitor of Fyn kinase S -acylation [48], this molecule has been generally considered to be a pan-inhibitor of S -acylation and has been shown to perturb various S -acylation events in cells.

2-Bromohexadecanoic acid, also known as 2-Bromopalmitic acid, is a long chain 2-haloalkanoic halogenated fatty acid that is commonly used as a building block in various organic reaction such as 2′-(2-bromohexadecanoyl)-docetaxel synthesis.

Here, we present the synthesis and evaluation of a click-enabled 2BP analogue and the corresponding CoA conjugate to explore the targets and mechanism of 2BP inhibition in cells, and annotate the consequences of promiscuous 2BP inhibition in palmitoylation analysis.

2-Bromohexadecanoic acid is a PPARδ agonist. It has also been shown to inhibit fatty acid oxidation, inhibit DHHC-mediated palmitoylation [2], and promote glucose uptake in rat cardiac cells and the insulin-sensitive murine fibroblast line A31-IS [3]. Choose from one of the most recent versions: Don't see the Right Version?

2013年9月20日 · 2-Bromohexadecanoic acid, or 2-bromopalmitate, was introduced nearly 50 years ago as a nonselective inhibitor of lipid metabolism. More recently, 2-bromopalmitate re-emerged as a general inhibitor of protein S-palmitoylation.

2-BP (2-Bromohexadecanoic acid)是一种不可代谢的棕榈酸酯类似物，可作为 棕榈酰化（palmitoylation） 抑制剂，抑制 棕榈酰基转移酶 (palmitoyl acyl transferase，PAT) 对MyrGCK (NBD)和FarnCNRas (NBD)的活性，IC50均接近4 µM。 2-Bromohexadecanoic acid 可直接且不可逆地抑制所有 DHHC (Asp-His-His-Cys) 蛋白的棕榈酰转移酶活性。

2024年3月15日 · In this study, we found that 2-bromopalmitate (2 BP), a previously defined palmitoylation inhibitor, depletes LD across all studied cell lines and exerts remarkable antiviral effects on different coronaviruses.

2023年10月23日 · UWB Modules Type 2BP Murata Type2BP is the ultra small UWB module which includes NXP's SR150 UWB chipset, clock, filters and peripheral components. Ideally suited for general IoT devices including battery operated devices.

This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

2008年1月8日 · What is a 2BP file? Bitmap or raster image format used for storing images on Pocket PC PDA devices; may be created by converting images saved in other formats using Microsoft ActiveSync; can be viewed on PCs and directly on a Pocket PC device with various software programs.

Cell behaviour was monitored in the presence of the protein palmitoylation inhibitor 2-bromopalmitate (2BP). Here, we observed a significant reduction in neuronal differentiation in the 2BP-treated cell model.

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2013年7月11日 · 2-Bromohexadecanoic acid, or 2-bromopalmitate, was introduced nearly 50 years ago as a nonselective inhibitor of lipid metabolism. More recently, 2-bromopalmitate re-emerged as a general inhibitor of protein S-palmitoylation.

2-溴十六烷酸 2-Bromohexadecanoic acid (2-Bromopalmitate; 2- BP) 是一种棕榈酰化抑制剂，靶向 DHHC (Asp-His-His-Cys) 蛋白棕榈酰转移酶。 2-Bromohexadecanoic acid 抑制 GSDME-C 的棕榈酰化，抑制 BAK/BAX-Caspase 3-GSDME 通路介导的焦亡 (pyroptosis)。 IGF2 BP 1-IN-1 (Compound A11) 是一种 IGF2BP1 抑制剂，可抑制下游信号传导。 IGF2 BP 1-IN-1 与 IGF2 …

2-Bromohexadecanoic acid, also known as 2-Bromopalmitic acid, is a long chain 2-haloalkanoic halogenated fatty acid that is commonly used as a building block in various organic reaction such as 2′- (2-bromohexadecanoyl)-docetaxel synthesis.

2013年7月11日 · While the α-brominated fatty acid 2bromopalmitate (2BP) is the most commonly used small molecule tool to study DHHC functions in live cells, its frequent use obscures its promiscuity, poor ...