Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown ...

Cytochrome P450 (P450) 2E1 is the major P450 enzyme involved in ethanol metabolism. That role is shared with two other enzymes that oxidize ethanol, alcohol dehydrogenase and catalase. P450 2E1 is also involved in the bioactivation of a number of low molecular weight cancer suspects, as validated in …

Cytochrome P450 (P450) 2E1 is the major P450 enzyme involved in ethanol metabolism. That role is shared with two other enzymes that oxidize ethanol, alcohol dehydrogenase and catalase. P450 2E1 is also involved in the bioactivation of a number of ...

计算器或电脑表达10的幂是一般是用E或e，也就是e2表示100。 科学记数法是一种记数的方法。 把一个数表示成a与10的n次幂相乘的形式（1≤|a|<10，n为整数），这种记数法叫做科学记数法。 例如：19971400000000=1.99714×10^13。 科学记数法的形式是由两个数的乘积组成的。 表示为a×10^b（aEb），其中一个因数为a（1≤|a|<10），另一个因数为10^n。 科学记数法是一种数学专用术语。 将一个数表示成 a×10的n次幂的形式，其中1≤|a|<10，n为整数，这种记数方法叫科 …

Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity and cancers (e.g. lung and bladder cancer), since it is responsible for metabolizing a number of medications and environmental toxins to reactive intermediate metabolites. CYP2E1 was recently found to be the highest expre …

2024年12月24日 · CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with CYP2E1 include Alcoholic Liver Cirrhosis and Alcohol Use Disorder. Among its related pathways are Enflurane Pathway, Pharmacokinetics and Oxidation by cytochrome P450.

细胞色素P450 2E1(cytochrome P450 2E1，CYP2E1)是一种主要位于肝细胞的化合物和毒物的代谢酶,是CYP450代谢酶系家族中的重要一员。 它在酒精、四氯化碳、硫代乙酰胺、对乙酰氨基酚、二甲基亚硝胺等毒性底物的代谢和活化中起着重要作用 [ 2 - 3 ] 。

Cytochrome P450 2E1 is likely a sensor of diverse pathophysiological factors and states in the myocardium. Upregulated cytochrome P450 2E1 has multiple pathophysiological roles in the heart, including increase oxidative stress and apoptosis as well as energy supply to meet the energy demand of the heart in certain disease states.

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress.

本文以代谢小分子职业和环境化学毒物和药物的细胞色素 P450 2E1 为例，系统介绍了线粒体细胞色素 P450 2E1( mtCYP2E1) 的分布特征、蛋白结构和功能及其信号转移机制，总结了mtCYP2E1 在常见毒物毒性中的作用，并就未来的研究趋势做出了展望。