2019年10月1日 · This review summarizes both 3' UTR functions-the regulation of mRNA and protein-based processes-and highlights how each 3' UTR function was discovered with a focus on experimental approaches used and the concepts that were learned.

3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and translation. In addition, 3′ UTRs can establish 3′ UTR-mediated protein–protein interactions ...

Here we review available information about human 3′ UTRs, known classes of 3′ UTR cis elements, evidence that supports the importance of 3′ UTRs in lung disease, and recent progress toward transcriptome-wide analysis of 3′ UTRs.

2017年11月27日 · 3'-untranslated regions (3'-UTRs) are the noncoding parts of mRNAs. Compared to yeast, in humans, median 3'-UTR length has expanded approximately tenfold alongside an increased generation of alternative 3'-UTR isoforms.

2024年2月1日 · We propose that 3′ UTR variants that disrupt (or create) specific types of regulatory elements are more likely to alter function and contribute to disease, aiding in the identification and interpretation of pathogenic 3′ UTR variants.

In this review, we discuss the diverse modes of translational regulation by 3′-UTR-binding proteins and the experimental and conceptual advances provided by current high-throughput technologies. Translation consists of initiation, elongation and termination steps but it is the initiation phase that is often targeted for regulation.

2012年5月1日 · In this review, we summarize the information known to date about 3'end processing, sequence characteristics including related binding proteins and the role of 3'UTRs in several selected signaling pathways to delineate their importance in the regulatory processes in mammalian cells.

2003年8月1日 · Adding to the complexity, 3′ untranslated regions (UTRs) often contain several regulatory elements that govern the spatial and temporal expression of an mRNA. Furthermore, several...

2020年5月12日 · Surprising roles for 3' UTRs are emerging beyond the regulation of protein synthesis and include roles as RBP delivery scaffolds and regulators of alternative splicing. Evidence is also emerging that 3' UTRs can be cleaved, leading to stable, isolated 3' UTR fragments which are of unknown function.

3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and translation. In ad-dition, 3′ UTRs can establish 3′ UTR-mediated protein–protein interactions (PPIs), and thus can transmit genetic information encoded in 3′ UTRs to proteins.