The 3C-like protease (3CL pro) or main protease (M pro), formally known as C30 endopeptidase or 3-chymotrypsin-like protease, [2] is the main protease found in coronaviruses. It cleaves the …

Japan has been preventing an explosive outbreak of COVID-19 by focusing on avoiding the so-called “Three Cs” (closed spaces, crowded places, and close-contact settings), key findings of …

Among the few available targets for anti-coronavirus drug development, 3CL pro, which is a key protein involved in the replication and transcription of coronaviruses, has become an important …

None of the efficacious antiviral agents against human CoVs have been approved yet. 3C-like protease (3CL pro) is an attractive target for antiviral intervention due to its essential role in …

2024年1月15日 · The development of effective antiviral drugs could serve as the ultimate piece of the puzzle to curbing this global crisis. 3-chymotrypsin-like protease (3CLpro), with its …

The SARS-CoV-2 3C-like protease (3CLpro), which is critical for viral replication and transcription, has been recognized as an ideal drug target. Herein, it is identified that three herbal …

The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication. …

2023年8月18日 · 3CL pro is an attractive target for the treatment of COVID-19. Using the scaffold hopping strategy, we identified a potent inhibitor of 3CL pro (3a) that contains a thiocyanate …

2023年5月5日 · The viral 3-chymotrypsin-like protease (3CL pro) is an essential enzyme for replication with high homology in the active site across CoVs and variants showing an almost …

2020年8月19日 · We describe herein the structure-guided optimization of a series of inhibitors of the coronavirus 3C-like protease (3CLpro), an enzyme essential for viral replication. The …