Cell | 快速40S扫描开启真核翻译启动新发现！ - 知乎专栏
广泛的生化、结构和遗传分析表明，43s pic在多蛋白eif4f复合物（eif4a、eif4e和eif4g）促进的封端mrna的5‘末端附近结合，并通过5‘非翻译区（5’utr）定向移动，以搜索第一个遇到的起始密 …
Rapid 40S scanning and its regulation by mRNA structure during ...
2022年11月23日 · Extensive biochemical, structural, and genetic analyses suggest that the 43S PIC binds near the 5′ end of a capped mRNA facilitated by a multi-protein eIF4F complex …
蛋白质翻译的起始阶段（一） - 知乎 - 知乎专栏
eif3可以与40 s小亚基的多个位点结合，环绕整个小亚基，还可与多种起始因子相互作用，募集并调节其精细定位，从而形成多因子复合物（mfc）。 酵母和兔的40 S亚基与eIF3复合物。
eIF4E: New Family Members, New Binding Partners, New Roles
Eukaryotic initiation factor 4E (eIF4E) has long been known as the cap-binding protein that participates in recruitment of mRNA to the ribosome. A number of recent advances have not …
与 4EGI-1 复合的真核翻译起始因子 eIF4E 的结构揭示了解离 eIF4G …
40S 粒子的有效募集对于编码癌蛋白和生长促进因子的 mRNA 的翻译尤为重要，这些 mRNA 通常包含复杂的 5' UTR，需要有效启动。 因此，抑制 eIF4E/eIF4G 相互作用已成为开发抗癌剂的 …
The C Terminus of Initiation Factor 4E-Binding Protein 1 Contains ...
Eukaryotic initiation factor 4E (eIF4E) binds the mRNA cap structure and forms eIF4F complexes that recruit 40S subunits to the mRNA. Formation of eIF4F is blocked by eIF4E-binding …
Human eukaryotic initiation factor 4G directly binds the 40S …
2024年5月1日 · Messenger RNA (mRNA) recruitment to the 40S ribosomal subunit is mediated by eukaryotic initiation factor 4F (eIF4F). This complex includes three subunits: eIF4E (m 7 G cap …
The structure of a human translation initiation complex reveals two ...
2024年1月29日 · eIF4E stabilizes the binding of mRNA to eIF4G–eIF4A 36 and stimulates the helicase activity of the eIF4F bound eIF4A 69. Selective 40S ribosome profiling has indicated …
Toward the mechanism of eIF4F-mediated ribosomal attachment to ...
2016年7月1日 · Ribosomal attachment to mammalian capped mRNAs is achieved through the cap-eukaryotic initiation factor 4E (eIF4E)-eIF4G-eIF3-40S chain of interactions, but the …
Human eukaryotic initiation factor 4G directly binds the 40S
2024年4月4日 · Messenger RNA (mRNA) recruitment to the 40S ribosomal subunit is mediated by eukaryotic initiation factor 4F (eIF4F). This complex includes 3 subunits: eIF4E (m 7 G cap …