4-1BB是在免疫系统的多种细胞上表达的共刺激受体，特别是在CD8+ T细胞上。 由于其广泛的表达，和4-1BB增强强效和持久免疫效应的能力，使4-1BB成为癌症免疫治疗的临床靶标。 利用配体4-1BBL或激活型4-1BB单抗激活4-1BB，可刺激T细胞和抗原提呈细胞增殖并分泌细胞因子，提高机体的抗肿瘤免疫应答水平。 4-1BB又名 CD137，和 OX40 同属肿瘤坏死因子（TNF）受体家族的成员，由 肿瘤坏死因子受体超家族 成员9（TNFRSF9）基因编码。 人4-1BB位于染色 …

2024年12月25日 · The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells.

Tumor necrosis factor ligand superfamily member 9 also known as 4-1BB ligand or 4-1BBL or CD137L is a protein that in humans is encoded by the TNFSF9 gene. [5] 4-1BBL is a type 2 transmembrane glycoprotein receptor that is found on APCs (antigen presenting cells) and binds to 4-1BB (also known as CD137).

2024年12月25日 · TNFRSF9 (TNF Receptor Superfamily Member 9) is a Protein Coding gene. Diseases associated with TNFRSF9 include Immunodeficiency 109 With Lymphoproliferation and Primary Immunodeficiency With Predisposition To Severe Viral Infection.

2024年1月4日 · Since its initial description 35 years ago as an inducible molecule expressed in cytotoxic and helper T cells, 4-1BB has emerged as a crucial receptor in T-cell-mediated immune functions....

4-1BB是在免疫系统的多种细胞上表达的共刺激受体，特别是在CD8+ T细胞上。 由于其广泛的表达，和4-1BB增强强效和持久免疫效应的能力，使4-1BB成为癌症免疫治疗的临床靶标。 也叫CD137，和OX40同属肿瘤坏死因子（TNF）受体家族的成员，由肿瘤坏死因子受体超家族成员9（TNFRSF9）基因编码。 人4-1BB位于染色体1p36，全长255aa，包含17aa信号肽、169aa的胞外区、27aa跨膜区（p.187–213）和42aa的胞内区。 小鼠4-1BB位于小鼠4号染色体75.5 cM …

In-depth analysis revealed that 4-1BB-mediated anti-cancer effects are based on its ability to induce activation of cytotoxic T lymphocytes (CTL), and among others, high amounts of IFN-γ. In this review, we will discuss the various aspects of 4-1BB-mediated anti-tumor responses, the basis of such responses, and future directions.

4-1BB (CD137) is being thought of as an attractive target for immunotherapy of many human immune diseases based on encouraging results with 4-1BB agonistic antibody treatment in mouse models of cancer, autoimmune disease, asthma and …

gnc-039将通过同时结合egfrviii、pdl1、cd3、41bb四个靶点，激发机体形成特异性肿瘤免疫杀伤，穿透血脑屏障、克服肿瘤靶点异质性表达、逆转抑制性的免疫微环境，从而实现肿瘤的消除。

2024年10月21日 · 4-1BB是这一种T细胞共刺激免疫检查点分子，也称为CD137或TNF受体超家族成员9 （TNFRSF9）。 4-1BB与其主要配体4-1BBL的相互作用可正向调节T细胞免疫，介导T细胞的生存和增殖。 用激动性抗体靶向4-1BB是一种有前途的免疫肿瘤学方法，使其成为癌症免疫治疗发展中一个有吸引力的靶点。 4-1BB的表达. 4-1BB表达主要发现于活化的细胞毒性CD8+T细胞和辅助CD4+细胞的表面。 T细胞激活后可在NK细胞、B细胞、单核细胞和DC上诱导4-1BB表达 …