46521 was completed at Swindon in February 1953 at a cost of £13,756 as part of the last batch of locomotives of the class built. BR motive power depot allocations. 46521 was transferred from the Western Region to the London Midland Region in September 1963 when Machynlleth depot was transferred to London Midland Region Control.

On 27 April 2013, No. 46521 derailed on the trap points at Quorn and Woodhouse on the Great Central Railway following a misunderstanding between the signalman and the locomotive's crew. The derailment was captured on video by a visitor and subsequently posted on YouTube.

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2019年9月13日 · 46521 – Operational on the Great Central Railway in BR Lined Green with Early Crest, Owned by Charles Newton and Loughborough Standard Locomotives Group Ltd (50/50). Following a similar working career to 46512, withdrawal for 46521 came in March 1967.

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One such was the Ivatt 2MT (see No.46521) a state of the art small locomotive introduced in the immediate post war era in accordance with latest design techniques. The first Ivatt 2MT appeared from Derby in 1946 and the last emerged from Swindon in March 1953.

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