2019年10月30日 · The Defense Information Systems Agency (DISA) has begun the implementation phase for the Fourth Estate Network Optimization Initiative and will now begin building the network for 14 defense agencies. The endeavor will standardize equipment, enhance cybersecurity, improve interoperability and save significant money, DISA officials say.

2020年12月1日 · The 4ENO initiative aims to bring 22 of the support agencies’ networks into one consolidated service and support operation run by DISA. Agencies in the Fourth Estate, which includes operations like the Defense Logistic Agency, currently operate their own IT systems and help desks, creating redundancies and security weaknesses, officials have ...

2022年2月28日 · Under the indefinite-delivery, indefinite-quantity Defense Enclave Services contract, Leidos will lead what DISA calls the Fourth Estate Network Optimization (4ENO) initiative — an effort to modernize and move the Department of Defense‘s 22 Fourth Estate agencies and field activities to a single platform.

2020年11月12日 · The 4ENO program is a bold, aggressive reform designed to implement structural change by creating an IT enterprise that is more modern, more secure, and more capable for 13 Defense Agencies and...

The 4ENO program conducts physical site surveys at DAFA sites to gather necessary information, such as: assess cable plant compliance with industry/federal/DoD standards, LCR requirements, HVAC/power/rack space to support DoDNet standard equipment, and other infrastructure/network data to plan for DoDNet migration. 4ENO Site Surveys and Standards

2022年2月28日 · Leidos will manage the Fourth Estate Network Optimization (4ENO) initiative — an effort to modernize and move the Department of Defense's 22 Fourth Estate agencies and field…

2021年4月27日 · 2021 is a big year for DISA as it begins moving all DOD components to a single services network. The Defense Information Systems Agency has begun shifting the Defense Department’s dozens of support...

2019年10月31日 · 据美国陆海空通信和电子协会（AFCEA）网站10月30日消息，美国国防信息系统局（DISA）已进入“第四等级网络优化（the Fourth Estate Network Optimization，4ENO）计划”实施阶段，将开始为14个国防机构搭建网络。

Here, the crystal structure of oxidized Nm23-H1 is presented. It reveals the formation of an intramolecular disulfide bond between Cys4 and Cys145 that triggers a large conformational change that destabilizes the hexameric state.

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