XBP1s activates METTL3/METTL14 for ER-phagy and
2024年8月1日 · XBP1s facilitated RNA m6A methylation by activating transcription of METTL3 and METTL14. m6A methylation mediated ER-phagy by stabilizing CALCOCO1 and p62 …
IRE1α inhibitor enhances paclitaxel sensitivity of triple-negative ...
2024年6月18日 · We found that XBP1 splicing events were naturally increased in long-term paclitaxel-treated MDA-MB-231-PTXR and 4T1-PTXR (Fig. 1H), which may promote cancer …
Direct inhibition of tumor hypoxia response with synthetic ...
2024年8月30日 · Here, we report a strategy to create synthetic transcriptional repressors (STRs) that mimic the basic leucine zipper domain of XBP1 and recognize UPRE and HRE motifs. A …
IRE1 signaling increases PERK expression during chronic ER stress
2024年4月18日 · In this study, we demonstrate cross talk between the IRE1 and PERK branches of the UPR, wherein IRE1 via XBP1s signaling helps to sustain PERK expression during …
A single-cell transcriptomic landscape of innate and adaptive ...
2022年3月8日 · Notably, one cluster on the 4T1 (cluster 3) displayed a gene signature typical of plasma B cells (high expression of Cd27, Cd38, Xbp1) [39, 40] that was not observed in the …
IF=15.881 | 极化巨噬细胞以降低肿瘤对PD-1免疫疗法的耐受性
接下来，研究团队建立4t1乳腺癌模型，验证纳米乳剂在体内的作用。 实验数据显示，α-TK有效降低了XBP1的表达，使M2细胞重极化为M1表型，延缓了肿瘤的生长。
The role of the unfolded protein response in cancer progression: …
2018年10月10日 · The RNase domain cleaves a 26-nucleotide intron within unspliced X Box binding Protein 1 (XBP1) or XBP1u mRNA. The resulting fragments are ligated by RNA 2′,3′ …
A Novel Metastatic Estrogen Receptor-Expressing Breast Cancer …
2023年12月9日 · To create a model of antiestrogen responsive BC with spontaneous metastasis, we developed a mouse model of 4T1.2 triple-negative (TN) breast cancer with virally …
Genetic Targeting of the Active Transcription Factor XBP1s to …
2012年2月1日 · XBP1s/DC potentiates NeuEDhsp70 genetic vaccine to elicit therapeutic CD8-dependent antitumor immunity against established breast tumor 4T1.2-Neu and attenuate …
New insights into IRE1α activation and function in anti-tumor …
2022年5月11日 · Its targets are X-box protein 1 (XBP1) mRNA, from which IRE1α removes a short intron producing XBP1 spliced (4), as well as other mRNAs (and miRNAs) whose …
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